血清载脂蛋白B对丙肝患者焦虑抑郁的影响

Effect of serum Apo B in patients with hepatitis C on anxiety depression

目的探讨血清载脂蛋白B(Apo B)对慢性丙型病毒性肝炎患者焦虑抑郁的影响。方法选取自2011年6月~2015年6月于监测点进行治疗的丙肝患者80例作为本次研究的观察组,选取同一时期于监测点进行体检且各项指标都正常的健康成年人80例作为对照组。用免疫投射比浊法检测两组受试者的Apo B水平,并采用焦虑与抑郁自评量表(SAS&SDS心理测验)对两组受试者进行测试。比较各组受试者血清Apo B水平的差异。结果轻度、中度和重度焦虑组患者血清Apo B值(0.35±0.12 g/L、0.36±0.14 g/L、0.36±0.13 g/L)分别较对照组(0.89±0.18 g/L)有显著降低(P<0.05),轻度、中度、重度焦虑组患者Apo B值(0.35±0.12 g/L、0.36±0.14 g/L、0.36±0.13 g/L)相比无明显差异(P>0.05);轻度、中度和重度抑郁症组患者Apo B值(0.37±0.12 g/L、0.23±0.11 g/L、0.14±0.14 g/L)与对照组相比明显下降,中度与轻度抑郁组相比血清Apo B水平明显下降,重度与中度抑郁组相比血清Apo B水平明显下降,差异均具有统计学意义(P<0.05)。结论慢性丙型病毒性肝炎患者伴发焦虑抑郁症与血清载脂蛋白B水平的下降有关,血清载脂蛋白B水平的下降与患者抑郁症程度呈相关性,与患者焦虑程度无明显相关性。

Objective To investigate the effect of serum apolipoprotein B （B Apo） on anxiety and depression in patients with chronic hepatitis C virus infection. Methods 80 cases were selected from June 2011 to June 2015 in our observation point for treatment in patients with hepatitis C as the observation group, selected the same period in our observation point for medical examination and the indicators are normal healthy adults in 80 cases as control group. The B Apo levels of two groups were tested by Olympus3200 type automatic biochemical analyzer, and the self rating anxiety and serf rating Depression Scale （SAS＆SDS psychological test） was used to test the two groups of subjects. The differences of serum B Apo levels were compared among the subjects in each group. Results Mild anxiety group, serum values of Apo B in patients with moderate and severe anxiety group anxiety group （0.35± 0.12 g/L, 0.36 ± 0.14 g/L, 0.36 ±0. 13 g/L）, respeetiw-ly, compared with the control group （0.89 ±0. 18 g/L） had significantly lower （P〈0.05）, mild anxiety group, moderate anxiety group, patients with severe Apo B value anxiety group （0.35 ± 0.12 g/L, 0.36 ± 0.14 g/ L, 0.36 ± 0.13 g/L） no significant difference compared （P〉 0.05）; group mild depression, moderate depression group and the group of patients with severe depression Apo B value （0.37 ± 0.12 g/L, 0.23± 0.11 g/L, 0.14 ± 0.14 g/L） was significantly decreased compared with the control group, mild depression and moderate depression group compared serum Apo B levels were significantly decreased, severe depression and moderate depression compared serum Ap~., B levels were significantly decreased, the differences were statistically significance （P〈0.05）.Conchrsions Chrunic hepatitis C virus hepatitis patients with depression or anxiety and serum contained apo B levels decreased, and the levels of serum load of Apo B levels decreased with the degree of depression was positively correlated, and the anxiety level of patients with no significant correlation.