华北油田矿区妇女人乳头状瘤病毒感染现状及相关因素分析

Prevalence of human papillomavirus (HPV) infection and its related factors in the mining area of Huabei oil field

目的分析探讨华北油田矿区妇女人乳头状瘤病毒感染情况以及相关因素。方法对2016年1-12月在医院进行体检746例华北油田矿区女性的宫颈脱落细胞标本进行人乳头状瘤病毒(HPV)基因分型检测,并通过问卷调查研究其相关影响因素。结果本研究746例女性中有197例女性发生HPV感染,感染率为26.41%;HPV基因型检测结果发现,共检测到24种HPV亚型,其中HPV感染呈现阳性排在前5位的亚型分别为HPV16、HPV58、HPV52、HPV18以及HPV33亚型,分别占29.44%、12.18%、8.63%、6.09%和4.57%;31~35岁女性HPV感染率最高为34.73%;采用logistic多变量分析显示,女性年龄≤35岁、初次性生活年龄≤20岁、妊娠次数≥3、性伴侣数≥2个均是HPV感染发生的独立危险因素(P<0.05)。结论 HPV感染在华北油田矿区妇女中具有较高的感染率,HPV主要亚型为HPV16、HPV58、HPV52、HPV18和HPV33,HPV感染多发生于年龄≤35岁女性中,影响HPV感染发生的危险因素包括女性初次性生活年龄、妊娠次数、性伴侣个数等。

OBJECTIVE To analyze the infection of human papillomavirus （HPV） and related factors in the mining area of Huabei oil field.METHODS HPV genotyping was performed on the cervical exfoliative cells from 746 women in Huaibei oil field who were examined in our hospital from Jan.2016 to Dec.2016,and the relevant influencing factors were investigated by questionnaire.RESULTS Among 746 cases of women,197 cases occurred HPV infection,and the infection rate was 26.41%.HPV genotyping showed that 24 HPV subtypes were detected,in which HPV16,HPV58,HPV52,HPV18 and HPV33 subtypes were the most common HPV subtypes,accounting for 29.44%,12.18%,8.63%,6.09% and 4.57%,respectively.The highest incidence of HPV infection was in the age group of 31 to 35 years old,and the infection rate was 34.73%.Logistic multivariate analysis showed that the independent risk factors of HPV infection were female age ≤35 years old,the first sexual life age ≤20 years old,pregnancy frequency ≥3 times and sex partners ≥2 （P〈0.05）.CONCLUSION HPV infection has a high infection rate in women of the mining area of Huabei oil field,and the main subtypes are HPV16,HPV58,HPV52,HPV18 and HPV33.HPV infection mainly occurs in women with age ≤ 35 years old,and the risk factors for HPV infection include the age of women＆#39;s first sexual life,pregnancy times,and number of sexual partners.