儿童化脓性脑膜炎病原菌及耐药性与醒脑静治疗效果研究

Pathogenic bacteria and their drug resistance of children with purulent meningitis and the treatment effect of Xingnaojing

目的研究儿童化脓性脑膜炎病原菌、耐药性及醒脑静在该类患儿中的治疗效果,为儿童化脓性脑膜炎的诊断与治疗提供依据。方法选取2015年5月-2016年5月医院收治的化脓性脑膜炎患儿66例,进行病原菌及其耐药性检测,将66例患儿随机分为两组,对照组33例患儿进行常规治疗,观察组33例患儿则在对照组的基础上加用醒脑静进行治疗,统计并比较两组患儿治疗总有效率。结果 66例化脓性脑膜炎患儿共检出66株病原菌,其中肺炎链球菌检出率最高占36.36%,明显高于其他病原菌检出率,差异有统计学意义(P<0.05);而常见病原菌对左氧氟沙星、哌拉西林及头孢唑林的耐药率相对较高,明显高于对其他药物的耐药率;治疗总有效率观察组患儿为90.91%,明显高于对照组患儿69.70%,差异有统计学意义(P<0.05)。结论儿童化脓性脑膜炎病原菌主要以肺炎链球菌为主,其耐药性较为明显,同时醒脑静在此类患儿中的应用效果较好。

OBJECTIVE To investigate the pathogenic bacteria and their drug resistance of children with purulent meningitis and the treatment effect of Xingnaojing in the children,so as to provide targeted evidence for the diagnose and treatment of children with purulent meningitis.METHODS A total of 66 children with purulent meningitis in our hospital from May 2015 to May 2016 were selected as the study objects,and the pathogenic bacteria and their drug resistance were detected.The 66 children were randomly divided into two groups,33 children in control group were treated with conventional treatment,33 children in observation group were treated with Xingnaojing on the basic treatment of control group,and the total effective rates of the two groups were analyzed and compared.RESULTS Totally 66 strains of pathogenic bacteria were detected form 66 children with purulent meningitis,the highest detection rate was Streptococcus pneumoniae,with the rate of 36.36 %,which was significantly higher than that of other pathogens.The drug resistant rates of common pathogenic bacteria to ampicillin,piperacillin and cefazolin were relatively high,which were significantly higher than those of other drugs,and the total effective rate of observation group was 90.91%,which was significantly higher than 69.70% of control group （P〈 0.05）.CONCLUSION The pathogenic bacteria of children with purulent meningitis is mainly Streptococcus pneumonia,the drug resistance is obvious,and the application effect of Xingnaojing in the children is good.