硝苯地平联合厄贝沙坦治疗糖尿病合并高血压的效果分析

Effect of Nifedipine Combined With Irbesartan in the Treatment of Diabetes Mellitus Complicated With Hypertension

目的观察和分析硝苯地平联合厄贝沙坦对于原发高血压合并2型糖尿病的临床疗效。方法选取在我院就诊的原发性高血压合并2型糖尿病的患者90例,随机分为对照组和观察组,每组各45例。对照组给予硝苯地平20 mg/d,观察组给予20 mg/d联合厄贝沙坦150mg/d。疗程为4周。疗程结束后,对两组患者的血压、血糖、胰岛素水平等进行比较。结果观察组血压下降幅度明显大于对照组,差异有统计学意义(P<0.05)。两组患者治疗前空腹血糖、餐后2 h血糖、糖化血红蛋白相比较,差异无统计学意义(P>0.05)。治疗后,观察组的空腹血糖、餐后2 h血糖以及糖化血红蛋白明显低于对照组(P<0.05)。两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论硝苯地平联合厄贝沙坦对于原发高血压合并2型糖尿病患者有良好的治疗效果,安全性高。

Objective To observe and analyze the clinical efficacy of nifedipine combined with irbesartan in the treatment of essential hypertension complicated with type 2 diabetes mellitus. Methods 90 cases of primary hypertension complicated with type 2 diabetes mellitus were selected and randomly divided into control group and observation group, 45 cases in each group, the control group was given nifedipine 20 mg/d, and the observation group was given 20 mg/d combined with irbesartan 150 mg/d. The course of treatment was 4 weeks. After the course of treatment, the blood pressure, blood sugar and insulin levels of the two groups were compared. Results The decrease of blood pressure in the observation group was significantly higher than that in the control group, the difference was statistically significant （P〈0.05）. The fasting blood glucose, postprandial 2 h blood glucose and glycosylated hemoglobin in the two groups were not statistically significant （P〉0.05）. After treatment, fasting blood glucose, postprandial 2 h blood glucose and glycosylated hemoglobin in the observation group were significantly lower than those in the control group （P〈0.05）. There were no statistically significant differences in adverse reactions between the two groups （P〉0.05）. Conclusion Nifedipine combined with irbesartan has good efficacy and safety in the treatment of primary hypertension with type 2 diabetes mellitus.