噻托溴铵粉吸入剂与沙美特罗替卡松吸入剂治疗重度COPD患者效果比较

The Comparison on Effect Between Tiotropium Bromide Powder for Inhalation and Salmeterol and Fluticasone Propionate Inhalation in the Treatment of Patients With Severe COPD

目的对噻托溴铵粉吸入剂与沙美特罗替卡松吸入剂治疗重度COPD患者临床效果进行比较。方法将我院收治的重度COPD患者102例随机分为A组及B组,各51例。A组患者给予噻托溴铵粉吸入剂治疗,B组患者给予沙美特罗替卡松吸入剂治疗,对比两组患者临床治疗效果。结果治疗后,A组FEV1、FVC、IC水平要高于B组(P<0.05);A组GQOL-74评分要高于B组(P<0.05);A组不良反应率要低于B组(P<0.05)。结论噻托溴铵粉吸入剂治疗重度COPD效果较沙美特罗替卡松吸入剂更优。

Objective To compared the effect of tiotropium bromide powder for inhalation and salmeterol and fluticasone propionate inhalation in the treatment of patients with severe COPD. Methods 102 cases of severe COPD patients admitted to our hospital were randomly divided into group A and group B, 51 cases in each group. A group was treated with tiotropium bromide powder for inhalation, fluticasone salmeterol treatment was given to patients in B group, clinical curative effect between two groups of patients was compared. Results After treatment, the levels of FEVt, FVC and IC in A group were higher than those in group B （P〈0.05）. The GQOL-74 score in group A was higher than that in group B （P〈0.05）. The adverse reaction rate in group A was lower than that in group B （P〈0.05）. Conclusion Tiotropium bromide powder for inhalation in the treatment of severe COPD achieves better effect than inhalation of salmeterol and fluticasone propionate.