中医药调控肝再生的研究进展及展望

Progress and prospect of regulation of liver regeneration by traditional Chinese medicine

中医药调控肝再生是防治肝病及其相关病证的重要策略,已形成的研究热点方兴未艾.近些年来取得的主要进展至少包括以下几个方面:调控肝损伤与肝再生失衡提高了中医/中西医结合防治肝病及其相关病证的临床疗效,"髓"为中心治疗靶点的研究进展揭示了中医/中西医结合防治肝病及其相关病证的疗效机制,整体动态微调早调的作用方式满足了肝再生调控复杂多变的需要,解决了单靶点调控肝再生疗效有限的关键科学问题,平衡协调的疗效考核与结局指标的综合判断为中医药调控肝再生的临床推广应用提供了途径和方法.

Using the traditional Chinese medicine to regulate liver regeneration is an important strategy for prevention and treatment of liver disease and the related diseases. In recent years, great progress has been made in this area, which includes at least the following several aspects. First, regulating liver injury and the imbalance of liver regeneration has improved the clinical curative effect of traditional Chinese medicine or combined traditional Chinese and Western medicine to prevent and treat liver disease and the relateddiseases. Second, the research progress of marrow-based therapeutic targets has revealed the mechanisms underlying the therapeutic effects of traditional Chinese medicine or combined traditional Chinese and Western medicine to prevent and treat liver disease and the related diseases. Third, the effect way of overall dynamic fine regulation or early regulation has met the complex and changeable needs of liver regeneration regulation. Moreover, it has overcome the limitations of using single targets to regulate liver regeneration. Also, balanced assessment of curative effects and comprehensive judgment of outcome indicators have facilitated the clinical application of traditional Chinese medicine to regulate liver regeneration.