蔗糖酶-异麦芽糖酶缺乏与腹泻的研究进展

Sucrase-isomaltase deficiency and diarrhea

蔗糖酶-异麦芽糖酶(sucrase-isomaltase,SI)是蔗糖酶在肠道内最主要的存在形式,是最丰富的肠道二糖酶,其包含了所有的蔗糖酶活性,大部分的异麦芽糖酶活性及60%-80%的麦芽糖酶活性.蔗糖酶-异麦芽糖酶缺乏症(sucrase-isomaltase deficiency,SID)是由于该二糖酶缺乏导致二糖吸收不良,肠道正常生理功能受损,机体营养不良,生长发育落后,甚至产生危及生命的胃肠道症状.其最主要的临床表现是腹泻.临床上通过调整肠道SI活性来治疗腹泻,并将SI活性用于临床诊断.本文主要阐述SID与腹泻的关系、研究进程以及诊疗手段,促进SI在药理方面的研究.

In the intestine, the most important form of sucrase is sucrase-isomaltase （SI）, which is an abundant enteric enzyme and accounts for all the sucrase activity, most of the isomaltase activity, and 60%-80 % of the maltose activity in the intestine. Sucrosease-isomaltase deficiency （SID） leads to poor absorption of disaccharides, intestinal dysfunction, malnutrition, limited body growth and development, and may even endanger the life. Diarrhea is the most important clinical manifestation of SID. Adjusting the intestinal SI activity has been used to treat diarrhea, and measurement of SI activity can be used for clinical diagnosis. In this paper, we discuss the relationship between SID and diarrhea.