三种中期妊娠终止方式的临床效果观察

Comparison of three methods for second-trimester labor induction

目的比较3种终止中期妊娠方法的临床效果。方法回顾性分析2013年1月1日至2015年12月31日于海军总医院终止中期妊娠的160例孕妇的临床资料,根据引产方式分为利凡诺组93例、米索前列醇组24例、水囊组43例。分析3组的引产成功率、引产时限、产后清宫率及并发症情况。结果米索前列醇组和水囊组的24小时引产成功率分别为31.6%和48.7%,优于利凡诺组(2.2%)。48小时引产成功率水囊组为92.3%,优于利凡诺组(75.3%),与米索前列醇组(89.5%)比较差异无显著性。利凡诺组、米索前列醇组及水囊组的引产时间分别为(43.5±11.1)小时、(29.0±14.7)小时及(27.0±12.4)小时,差异有显著性(P<0.05)。利凡诺组、米索前列醇组及水囊组的清宫率分别为78.7%、26.3%及25.6%,差异有显著性(P<0.05)。结论在引产时间、产后清宫率等方面米索前列醇与水囊类似,均优于利凡诺。

Objective To evaluate the effect of three methods for labor induction of 16-28 weeks＇ gestation. Methods Data of one hundred and sixty women who came for labor induction in 16-28 weeks＇ gestation at Navy General Hospital of Chinese PLA between January 1, 2013 and December 31, 2015 was collected and retrospective analysis was conducted. Success rate of induced labor, induction-to-delivery interval, curettage rate and complication were compared respectively according to different induction methods of rivanol, misoprostol and water balloon. Results There were higher induction success rates within 24 hours in the misoprostol group and water balloon group（31.6%, 48.7%） than in the rivanol group （2.2%, P〈0.05）. The success rates within 48 hours were higher in water balloon group 92.3% and misoprostol group 89.5% than rivanol group 75.3% （P=0.046）. Avarage induction-to-delivery intervals were significantly shorter in the misoprostol group and water balloon group[（29.0±14.7）h, （27.0±12.4）h）] than in the rivanol group[（43.5 ± 11.1）h, P〈0.05]. Significant difference was noted in postpartum curettage rate among misoprostol, water balloon and rivanol group（26.3%, 25.6% vs 78.7%, P〈0.05）. Conclusion Misoprostol and water balloon are equal with each other in induction-to-delivery interval and postpartum curettage rate and better than rivanol.