血浆VEGF MIC-1联合尿LAP在2型糖尿病肾病检测中的临床意义

Clinical significance of detection of plasma MIC-1 VEGF combined with urinary LAP in patients with type 2 diabetic nephropathy

目的分析血浆VEGF MIC-1联合尿LAP在2型糖尿病肾病检测中的临床意义,为2型糖尿病肾病患者的早期诊断提供新的思路及理论支持。方法选取2013年4月—2015年6月接收的41例2型糖尿病肾病患者作为实验组,另选取41例同期体检健康者作为健康组,对两组研究对象血液样本及尿液进行检测,对比观察两组研究对象血浆VEGF、MIC-1、尿LAP、肌酐、葡萄糖、尿素、CIM-1及GHb Alc水平。结果实验组血浆VEGF、MIC-1、尿LAP水平分别为(257.11±53.71)pg/ml、(3039.31±1027.12)pg/ml、(53.04±4.53)U/g Gr,而健康组各项指标水平分别为(18.89±5.51)pg/ml、(711.77±311.23)pg/ml、(32.23±5.22)U/g Gr,两组对比差异有统计学意义(P<0.05);实验组肌酐、葡萄糖、尿素、CIM-1及GHb Alc水平均明显高于健康组,差异有统计学意义(P<0.05)。结论可将血浆VEGF MIC-1及尿LAP作为诊断2型糖尿病肾病的检测指标,具有重要临床价值,值得推广运用。

Objective To study the clinical significance of the detection of plasma MIC - 1 VEGF combined with urinary LAP in patients with type 2 diabetic nephropathy, to provide new ideas and theoretical support for the early diagnosis of type 2 diabetic nephropathy patients. Methods A total of 41 patients with type 2 diabetic nephropathy from April 2013 to June 2015 were seIected as the experimental group, 41 healthy cases were selected as healthy group. Blood samples and urine of the two groups were detected, and the plasma levels of VEGF, MIC - 1, urine LAP, creatinine, glucose, u- rea, CIM - 1 and GHbAlc were compared between the two groups. Results The levels of plasma VEGF, MIC - 1 and urinary LAP in the experimental group were （257. 11 ±53.71 ） pg/ml, （3039. 31 ± 1027. 12） pg/ml, （53.04 ±4. 53） U/gGr, while the indicators of health group were （ 18.89 ± 5.51 ） pg/ml, （711.77 ± 311.23 ） pg/ml, （ 32. 23 ± 5.22） U/gGr, there was significant difference between the two groups （P 〈 0. 05 ） ;In experimental group, creatinine, glucose, urea, CIM - 1 and GHbAlc were significantly higher than the healthy group, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Plasma MIC - 1 VEGF and urinary LAP can be used as indicators of diagnosis of type 2 dia- betic nephropathy, which has important clinical value and is worth popularizing and applying.