高血压患者血清同型半胱氨酸水平分析

The analysis of serum homocysteine level in high blood pressure patients

目的：对高血压患者同型半胱氨酸水平与血压水平之间的关系进行研究与分析.方法：选取110例高血压患者,通过高压液相色谱法对患者同型半胱氨酸水平进行测定,另选110例非高血压患者作为对照组,对两组研究样本同型半胱氨酸水平差异进行分析,同时也对不同级别高血压患者同型半胱氨酸水平差异进行分析.结果：高血压组与非高血压组患者同型半胱氨酸水平分别为22.13±11.98μmol/L与11.34±2.46μmol/L,两组研究样本在该指标方面的差异P〈0.05有统计学意义;高血压1级、2级、3级患者同型半胱氨酸水平分别为10.11±3.02μmol/L、19.13±2.12μmol/L、27.19±6.22μmol/L,高血压级数越高,同型半胱氨酸水平越高.结论：有75%的高血压患者同型半胱氨酸水平呈现出升高的趋势,高血压患者血压水平与同型半胱氨酸水平之间存在着正相关系.

Objective： To study the relationship between homocysteine level and blood pressure in patients with essential hypertension. Methods： Select 110 cases of patients with hypertension and detect the homocysteine levels by high pressure liquid chromatography. Another 110 cases of non hypertensive patients were selected as the control group. The difference of homocysteine levels in the two groups and in patients with different levels of high blood pressure were analyzed. Results： The serum homocysteine levels in the hypertension group and non hypertension group were 22.13 ±11.98μmol/Land 11.34±2.46 μmol/L, the difference was statistically significant （P〈0.05） ; The levels ofhomocysteine in patients with grade 1,2,3 hypertension were 10.11±3.02 μmol/L, 19.13 ± 2.12μmol/L, 27.19 ±6.22μmol/L, respectively , the higher grade of hypertension, the higher levels of homocysteine. Conclusion： There was an increasing trend ofhomocysteine levels in 75% of the patients with hypertension, and there was a positive relationship between the level of blood pressure and homocysteine.