核因子κB与NO在脓毒症ARDS的关系及Ghrelin干预机制的研究进展

Roles of NF-κB and NO in sepsis-induced ARDS and the theraputic mechanism of Ghrelin

肺是脓毒症最早和最易受累的器官,可发生严重的ARDS.核因子κB （NF-κB）与一氧化氮（NO）在脓毒症ARDS时炎症反应的发生发展中具有重要的调节作用,发生脓毒症ARDS时,NF-κB活性增强,氧化应激产生大量NO,加剧炎症反应.胃生长激素释放素（Ghrelin）具有抗炎作用,对脓毒症ARDS能起到保护作用,其抗炎机制与调节NF-κB与NO的活性相关.

Sepsis is a leading cause of mortality,in which lung is usually the first falling organ,which can develop to a severe condition clinically defined as acute respiratory distress syndrome （ARDS）.Nuclear factor of kappa B （NF-κB） and nitric oxide （NO） are predominantmediators of inflammatory reaction of sepsis-induced ARDS.The activity of NF-κB will enhance during the pathophysiology,causing excessive oxidative stress,which lead to mass production of NO,eventually promotes inflammation.Ghrelin is suggested to have anti-inflammatory effects that can alleviate sepsis-induced ARDS because it can mediate the activity of NF-κB and NO.