血浆CX3CL1水平与急性脑梗死病情严重程度及预后的相关性

Association between level of plasma CX3CL1 and severity and prognosis of acute cerebral infarction

目的 探讨血浆CX3CL1水平与急性脑梗死患者病情严重程度及预后的关系.方法 收集139例急性脑梗死患者（病例组）及82名健康对照者（对照组）的临床资料及血浆,采用ELISA法测定其血浆CX3CL1水平.病例组患者于入院后24 h内行NIHSS评分,并于发病3个月后随访行mRS评分.将病例组患者根据NIHSS评分及mRS评分分别进行分组,比较各亚组间血浆CX3CL1水平有无差异.结果 病例组血浆CX3CL1水平明显低于对照组（P=0.009）,经Logistic回归分析显示血浆CX3CL1水平与急性脑梗死发病密切相关（OR=0.387,P=0.020）,且血浆CX3CL1水平与CRP呈负相关（r=-0.232,P=0.003）.急性脑梗死患者血浆CX3CL1水平与其入院后24 h内NIHSS评分呈负相关（r=-0.179,P=0.034）.预后不良组（mRS＆gt;2分）血浆CX3CL1水平显著低于预后良好组（mRS≤2分）,白细胞计数及CRP显著高于预后良好组（均P＜0.05）,血浆CX3CL1水平与急性脑梗死后3个月mRS评分呈负相关（r=-0.263,P=0.002）.Logistic回归分析提示血浆CX3CL1水平与急性脑梗死预后密切相关（OR=0.087,P=0.004）.结论 急性脑梗死患者的血浆CX3CL1水平较低,且血浆CX3CL1水平与急性脑梗死患者的病情严重程度及预后密切相关.

Objective To investigate the relationship between plasma CX3CL1 level and severity and prognosis of patients with acute cerebral infarction. Methods The clinical data and plasma of 139 acute cerebral infarction patients （case group） and 82 healthy controls （control group） were collected. Plasma CX3CL1 levels were determined by ELISA. Patients in case group were tested by NIHSS within 24 h after admission,and then tested by mRS after 3 months. Level of plasma CX3XL1 was compared between subgroups divided accord-ing to NIHSS score and mRS score in case group. Results Compared with control group,the level of plasma CX3CL1 in case group were significantly lower （P=0.009）. Logistic analysis showed that plasma CX3CL1 level was associated with the occurrence of acute cerebral infarction （OR=0.387,P=0.020）. And there was a signifi-cant negative correlation between CRP and plasma CX3CL1 level （r=-0.232,P=0.003）. There was a significant negative correlation between the plasma CX3CL1 level and the NIHSS score within 24 h after admission （r=-0.179,P=0.034）. Compared with good outcome patients （mRS＆gt;2）,the poor outcome patients （mRS≤2） had significant higher leukocyte count and CRP,and lower plasma CX3CL1 level （all P 〈 0.05）. And there was a significant negative correlation between the plasma CX3CL1 level and the mRS score after 3 months of acute ce-rebral infarction （r=-0.263,P=0.002）. Logistic analysis showed that plasma CX3CL1 level was associated with the prognosis of the patients （OR=0.087,P=0.004）. Conclusions The plasma CX3CL1 level of acute cerebral infarction patients was lower. And the plasma CX3CL1 level was significantly associated with the severity and prognosis of acute cerebral infarction patients.