缺氧条件下阴茎海绵体平滑肌细胞自噬的研究进展

Research progress of the autophagy of corpus cavernosum smooth muscle cells under the condition of hypoxia

大量研究表明,缺氧是勃起功能障碍(ED)独立的危险因素之一。长期以来,人们在缺氧性疾病引发ED机制方面的研究虽取得一定进展,但又始终未能完全阐明。近来,研究者们逐步将目光关注于缺氧对阴茎海绵体平滑肌的影响,细胞自噬便是其在缺氧条件下呈现的一种微观改变,可能对勃起功能障碍的发生、发展有一定作用。本文基于相关文献的阅读,对缺氧性ED患者阴茎海绵体平滑肌细胞中自噬的变化、调控机制、作用机制、意义等方面进行综述。

Most researches have shown that hypoxia is one of the independent risk factors of erectile dys-function（ED）. For a long time,studies have made progresses on the mechanism of ED caused by hypoxia,but it has not been fully clarified by now. Recently,researchers are paying increasing attention to the effect of hypoxia on cavernosum smooth muscle cells（CCSM）. Autophagy is a microscopic lesion under the condition of hypoxia,which have some effects on the development of ED. After consulting numerous relevant documents,this paper reviewed the change,regulatory mechanism,mechanism of action and significance of CCSM autophagy of patients with hypoxic ED.