慢性失眠伴焦虑抑郁患者血清炎症相关标志物研究进展

Research Progress of Serum Inflammatory Biomarkers in Chronic Insomnia Patients with Anxiety or/and Depression

慢性失眠是临床上常见的睡眠障碍,慢性失眠患者多伴有焦虑抑郁,慢性失眠是导致焦虑抑郁的重要危险因素,同时焦虑抑郁又会加重患者的慢性失眠,两者关系密切,相互影响,最终有可能进一步引发大脑认知功能损伤。慢性失眠和焦虑抑郁的发病机制目前尚不十分明确,最新研究提示慢性失眠伴焦虑抑郁可以导致机体内免疫机能及炎症反应的变化,现就慢性失眠伴焦虑抑郁患者血清炎症相关标志物研究进展进行综述。

Chronic insomnia is a common clinical sleep disorder and chronic insomnia patients often suffer with anxiety or/ and depression. Chronic insomnia is an important risk factor causing anxiety and depression. Meanwhile, anxiety and depression may aggravate chronic insomnia, their mutual influence can eventually trigger damage on cerebral cognition. The pathogenesis of chronic insomnia, anxiety and depression is not quietly clear. Studies suggest chronic insomnia accompanied with anxiety depression can lead to immune system dysfunction. Here we＇ll review research progress of serum inflammatory markers in chronic insomnia patients with anxiety or/and depression.