奥美拉唑治疗老年急性非静脉曲张性上消化道出血84例临床分析

Clinical analysis of omeprazole in the treatment of 84 senile acute non-variceal upper gastrointestinal bleeding cases

目的探讨奥美拉唑持续静脉滴注治疗老年急性非静脉曲张性上消化道出血的疗效。方法 168例老年急性非静脉曲张性上消化道出血患者,随机分成研究组和对照组,各84例。研究组应用奥美拉唑(洛赛克)静脉滴注治疗,对照组应用法莫替丁静脉滴注治疗。比较两组患者止血效果。结果研究组患者止血显效38例、占45.2%,有效34例、占40.5%,无效12例、占14.3%,总有效率为85.7%;对照组患者止血显效8例、占9.5%,有效46例、占54.8%,无效30例、占35.7%,总有效率为64.3%。研究组患者止血显效率、总有效率均高于对照组,差异具有统计学意义(P<0.05)。结论奥美拉唑持续静脉滴注治疗老年急性非静脉曲张性上消化道出血疗效显著,且明显优于法莫替丁静脉滴注治疗的效果。

Objective To investigate curative effect by continuous intravenous drip of omeprazole in the treatment of senile acute non-variceal upper gastrointestinal bleeding. Methods A total of 168 senile acute non- variceal upper gastrointestinal bleeding patients were randomly divided into research group and control group, with 84 cases in each group. The research group received intravenous drip of omeprazole （Losec） for treatment, and the control group received intravenous drip of famotidine for treatment. Hemostatic effects were compared between the two groups. Results The research group had 38 excellent hemostasis cases, accounting for 45.2%, 34 effective cases, accounting for 40.5%, and 12 ineffective cases, accounting for 14.3%, along with total effective rate as 85.7%. The control group had 8 excellent hemostasis cases, accounting for 9.5%, 46 effective cases, accounting for 54.8%, and 30 ineffective cases, accounting for 35.7%, along with total effective rate as 64.3%. The research group had all higher hemostasis excellent effective rate and total effective rate than the control group, and their difference had statistical significance （P〈0.05）. Conclusion Continuous intravenous drip of omeprazole shows excellent curative effect in the treatment of senile acute non-variceal upper gastrointestinal bleeding, and its effect is remarkably better than intravenous drip of famotidine.