强迫症患者自知力水平与启动反应抑制功能关系的ERP研究

Correlations between Insight in Obsessive-compulsive Disorder and Motor Response Inhibition

目的:探索强迫症患者自知力与反应抑制功能的关系。方法:记录42名强迫症患者(包括8名自知力不良的强迫症患者)和42名健康对照者在执行停止信号任务时诱发的ERPs。结果:与健康对照者相比,自知力不良和自知力良好组强迫症患者的抑制过程的反应时(Stop-signal reaction time,SSRT)更长(P<0.05),但是强迫症两个组别之间没有显著性差异。两组强迫症患者在抑制成功试次中的Stop-N2波幅值均显著大于健康对照者(P<0.05),两个强迫症组别之间无显著性差异。在抑制失败试次中,自知力良好的强迫症组的Stop-N2波幅值显著大于健康对照组(P<0.05)。结论:自知力不良的强迫症患者可能并不存在更严重的启动抑制功能的下降,强迫症的启动反应抑制功能下降可能独立于自知力水平。

Objective： The aim of this study was to examine the correlations between insight in obsessive-compulsive disorder and motor response inhibition. Methods： Event-related potentials（ERPs） were collected from 42 OCD patients（including 80CD patients with poor insight） and 42 healthy controls while they performed a stop signal task. Results： Stopsignal reaction time（SSRT） was longer in both good insight and poor insight OCD groups compared to control group（P〈0.05）. Larger Stop-N2 amplitudes were found in both of OCD groups in condition of inhibiting success（P〈0.05）. However, no significant differences were found between the two OCD groups. In condition of inhibiting failure. Conclusion： OCD patients with poor insight might have no more poorer performance on motor response inhibition, indicating that reduced motor response inhibition in OCD patients may be independent of their insight levels.