结肠癌患者血清中E-钙粘蛋白和半乳糖凝集素-9的表达水平及临床意义

Serum Levels of Galectin-1 and ACTC1 in Glioma Patients and Clinical Significance

目的分析与检测结肠癌患者血清中E-钙粘蛋白和半乳糖凝集素-9水平以及临床意义。方法选择结肠癌患者88例,健康体检者50例作为对照观察。采用酶联免疫吸附法检测两组血清E-钙粘蛋白和半乳糖凝集素-9水平。结果与对照组相比,结肠癌组血清E-钙粘蛋白和半乳糖凝集素-9水平显著降低(P<0.05)。血清E-钙粘蛋白和半乳糖凝集素-9水平与结肠癌患者年龄、性别、瘤灶直径、癌灶部位无明显相关性(P>0.05),与临床分期和肿瘤分化程度显著相关(P<0.05)。死亡组患者E-钙粘蛋白和半乳糖凝集素-9水平显著低于存活组(P<0.01)。结论结肠癌患者血清中E-钙粘蛋白和半乳糖凝集素-9水平明显降低,与结肠癌的恶性程度相关,对该病的临床预后评价具有重要价值。

Objective To investigate the serum levels of E-cadherin and Galectin-9 in colon cancer and clinical significance. Methods 88 patients with colon cancer were selected. 50 patients of healthy people were the control group. Levels of E- eadherin and Galectin-9 in serum samples were detected in both groups was analyzed. Results Levels of E-cadherin and Galec- tin-9 in colon cancer group were obviously lower than those of the control group （ P 〈 0.05 ）. Levels of E-cadherin and Galectin-9 were not related to age, gender, tumor diameter, and tumor site in colon cancer patients （ P 〉 0.05 ） , and were evidently related to stage and carcinoma ceil differentiation （P 〈 0.05 ）. Levels of E-cadherin and Galectin-9 in death group were remarkably lower than survival group （ P 〈 0.05 ）. Conclusion Levels of E-cadherin and Galectin-9 of colon cancer patients in serum are obviously decreased, are related with stage and carcinoma cell differentiation, and the effective indicators of clinical prognosis.