髓样细胞触发受体1在痛风性关节炎患者中的表达及意义

The expression of TREM-1 in patients with gouty arthritis and its clinical implication

目的分析髓样细胞触发受体1(TREM-1)在痛风性关节炎患者关节滑膜及外周血中的表达改变及意义。方法分析痛风性关节炎患者(观察组)的临床资料,采用免疫组化及酶联免疫吸附法检测滑膜及外周血中TREM-1的表达,并与健康体检者(对照组)外周血相关指标作对照。结果观察组外周血TREM-1、TNF-α、IL-6及血尿酸水平均显著高于对照者(P<0.01);观察组患者病变关节滑膜中TREM-1表达显著高于骨关节炎滑膜(t=69.570;P<0.01),TREM-1水平与TNF-α(r=0.878)、IL-6(r=0.903)及血尿酸(r=0.894)水平均呈现显著正相关(P<0.01)。结论痛风性关节炎患者病变滑膜及外周血TREM-1表达均升高,且与血尿酸及系统性炎症水平正相关。

Objective To identify the patterns of expression of TREM-1 in patients with gouty arthritis. Method The clinical data of the patients with gouty arthritis （the experimental group） were firstly reviewed and then the expression of TREM-1 in the synovial tissues and peripheral blood of the patients were tested and compared with the haematological indexes of the control group. Findings The levels of TREM-1, TNF-α, IL-6 and blood uric acid of the experimental group were considerably higher than those of the control group. The difference was statistically significant （ P 〈 0.01 ）. The level of TREM-I expression in the synovial tissues of the experimental group was higher than that of the osteoarthritis patients （ t =69. 570 ;P 〈 0.01 ）. The levels of TREM-1 had significant positive correlation with TNF-α （ r = 0. 878, P 〈 0.01 ） , IL-6 （ r = 0. 903, P 〈 0.01 ） and blood uric acid （ r = 0. 894,P 〈 0. 01 ）. Conclusion The expression of TREM-1 was higher in patients with gouty arthritis and associated with infla mmatory reaction and blood uric acid. It is an indicator of the occurrence and development of the disease.