摘要
目的分析髓样细胞触发受体1(TREM-1)在痛风性关节炎患者关节滑膜及外周血中的表达改变及意义。方法分析痛风性关节炎患者(观察组)的临床资料,采用免疫组化及酶联免疫吸附法检测滑膜及外周血中TREM-1的表达,并与健康体检者(对照组)外周血相关指标作对照。结果观察组外周血TREM-1、TNF-α、IL-6及血尿酸水平均显著高于对照者(P<0.01);观察组患者病变关节滑膜中TREM-1表达显著高于骨关节炎滑膜(t=69.570;P<0.01),TREM-1水平与TNF-α(r=0.878)、IL-6(r=0.903)及血尿酸(r=0.894)水平均呈现显著正相关(P<0.01)。结论痛风性关节炎患者病变滑膜及外周血TREM-1表达均升高,且与血尿酸及系统性炎症水平正相关。
Objective To identify the patterns of expression of TREM-1 in patients with gouty arthritis. Method The clinical data of the patients with gouty arthritis (the experimental group) were firstly reviewed and then the expression of TREM-1 in the synovial tissues and peripheral blood of the patients were tested and compared with the haematological indexes of the control group. Findings The levels of TREM-1, TNF-α, IL-6 and blood uric acid of the experimental group were considerably higher than those of the control group. The difference was statistically significant ( P 〈 0.01 ). The level of TREM-I expression in the synovial tissues of the experimental group was higher than that of the osteoarthritis patients ( t =69. 570 ;P 〈 0.01 ). The levels of TREM-1 had significant positive correlation with TNF-α ( r = 0. 878, P 〈 0.01 ) , IL-6 ( r = 0. 903, P 〈 0.01 ) and blood uric acid ( r = 0. 894,P 〈 0. 01 ). Conclusion The expression of TREM-1 was higher in patients with gouty arthritis and associated with infla mmatory reaction and blood uric acid. It is an indicator of the occurrence and development of the disease.
出处
《健康研究》
CAS
2017年第3期280-282,286,共4页
Health Research