急性脑梗死后睡眠障碍与认知障碍的相关性研究

Clinical study on correlation between sleep disorder and cognitive disorder after acute cerebral infarction

目的分析急性脑梗死后睡眠障碍与认知障碍的相关性。方法选取2014年1月—2015年12月我院神经内科收治的急性脑梗死后睡眠障碍患者80例作为观察组,同时随机选取急性脑梗死非睡眠障碍患者80例作为对照组,对2组患者进行蒙特利尔认知评估量表(MOCA)、简易智能状态检查(MMSE)评估,连线测试评估视空间功能(TMT)、执行功能(WCST)、词语流畅性测试(WFT),对患者情绪认知功能进行评估(HAMD与HAMA)。结果对照组各项睡眠参数均优于观察组,MOCA、MMSE、WCST总评分小于对照组,HAMD及HAMA评分均高于对照组,差异有统计学意义(P<0.05),两组TMT及WFT比较差异无统计学意义(P>0.05)。结论急性脑梗死后睡眠障碍可加重认知障碍,尽早对患者进行干预治疗,可有效改善睡眠及认知障碍,恢复脑组织功能,有利于预后恢复。

Objective To analyze the correlation between sleep disorder and cognitive disorder after acute cerebral infarction. Methods 80 patients with sleep disorder after acute cerebral infarction in the neurology department of Dexing people＇s hospital from January 2014 to December 2015 were selected as observation group, 80 acute cerebral infarction patients without sleep disorder were randomly selected and taken as control group. The Montreal cognitive assessment （MOCA）, mini-mental state examination （MMSE） in overall assessment of cognitive function of two groups were compared; The trail marking test was used to evaluate TMT, Wisconsin card sorting test （WCST）, verbal fluency test （WFT）, patients＇ emotional cognitive function （HAMD and HAMA）. Results The sleep parameters of control group were better than those of observation group, total scores of MOCA, MMSE, WCST were smaller than control group, HAMD and HAMA scores were higher than control group （P〈0.05）; There was no statistical difference in TMT and WFT between two groups （P〉0.05）. Conclusion Sleep disorder after acute cerebral infarction can aggravate cognitive disorder. Early intervention treatment for patients can effectively improve slrrp and cognitive disorder, recover brain function and facilitate prognostic recovery.