脑梗死急性期患者卒中后抑郁发生率及相关因素研究

Study on the incidence and related factors of ischemic stroke patients with depression after stroke

目的探讨脑梗死急性期患者卒中后抑郁(PSD)的发生率及相关因素。方法选择在我院住院的120例急性脑梗死患者,在其发病14 d时采用汉密尔顿抑郁量表(HAMD)进行评分,依据得分分为抑郁组(post-stroke depression,PSD)和非抑郁组。计算PSD的发生率,并比较2组患者之间情况,了解影响PSD发生的相关因素。结果 PSD总的发生率为38.3%;患者发病前性格、近期负性事件等都与PSD的发生有关(P<0.05);而与患者的性别、年龄、文化程度无明显关系(P>0.05);高血压、糖尿病与PSD的发生有关,并且危险因素越多,越易发生PSD(P<0.05);卒中次数、卒中病灶个数越多,越容易发生PSD(P<0.05),与卒中部位无相关性。结论脑梗死急性期PSD主要以轻、中度抑郁为主,PSD患者的发病前性格、近期负性事件、家庭关怀、收入及居住地都与PSD的发生都有比较密切的关系;多病灶患者PSD的临床发病率要高于单病灶患者;高血压、糖尿病与PSD的发生有关。

Objective To investigate the incidence and related factors of ischemic stroke patients with depression after stroke.Methods According to the scores of Hamilton Depression Scale （HAMi））assessed at 14 d after stroke, the 120 stroke patients were divided into PSD group and non-PSD group.We calculated the incidence of PSD, and compared the two groups in general between patients.Results The incidence of PSD is 38.3%;The study found that PSD patients ＇ character before the onset, recent negative life events, family care.at are associated with the occurrence of PSI） （P〈0.05）; And sex, age, culture degree had no significant relationship with the occurrence of PSD （P〉0.05） ; Vascular risk factors of hypertension, diabetes are related with the incidence of PSD, and more risk factors, more prone to PSD （P〈0.05） ; More stroke and stroke lesion number, more prone to PSD （P〈0.05）;From the stroke position, no significant statistical differences between the PSD group and the non PSD group.Conclusion Mild and moderate PSD are more common. PSI） patients ＇ character before the onset , recent negative life events, family care, income and place of residence are associated with the occurrence of PSD.Multifocal PSI） patients clinical incidence is higher than that of patients with single lesion. Vascular risk factors of hypertension, diabetes are related with the incidence of PSD