替勃龙小剂量替代治疗对绝经后妇女动脉粥样硬化的影响研究

Effect of low-dose Tibolone replacement therapy on atherosclerosis of postmenopausal women

目的探讨替勃龙小剂量替代治疗对绝经后妇女动脉粥样硬化(AS)的影响。方法选取上饶县第五人民医院收治的绝经后妇女AS患者80例,随机分为2组各40例,对照组未接受替勃龙小剂量替代治疗,观察组长期接受替勃龙小剂量替代治疗。比较2组血浆纤溶酶原激活物抑制物-1(PAI-1)和血浆组织纤溶酶原激活物(t-PA)含量、血脂及血清同型半胱氨酸(Hcy)水平。结果对照组PAI-1高于观察组,t-PA低于观察组,差异有统计学意义(P<0.05);对照组LDL-C、TG、TC、Hcy水平和AS发生率高于观察组,HDL-C低于观察组,差异有统计学意义(P<0.05)。结论替勃龙小剂量替代治疗可显著改善绝经后妇女血脂、PAI-1和t-PA水平,降低动脉粥样硬化形成,值得临床推广。

Objective To investigate the clinical effect of low-dose tibolone replacement therapy on atherosclerosis（AS）of postmenopausal women.Methods 80 postmenopausal women with AS in Shangrao county fifth people＇s hospital were randomly divided into two groups, 40 cases in each. Control group was not given low-dose tibolone replacement therapy, observation group received long-term low-dose tibolone replacement therapy. The plasminogen activator inhibitor-1 （PAI-1）,plasma tissue plasminogen activator （t-PA）content,blood lipid,serum homocysteine （Hcy）of two groups were compared. Results The PAI-1 of control group was higher than that of observation group, and t-PA was lower than observation group （P〈0.05）;The LDL, TG,TC,Hcy levels and the incidence of AS of control group were higher than those of observation group （P〈0.05）. Conclusion Low-dose tibolone replacement therapy can significantly improve blood lipid, PAI-1 and t-PA levels of postmenopausal women, decrease the formation of AS, which is worthy of clinical promotion.