摘要
目的:观察泊沙康唑用于造血干细胞移植(allo-HSCT)中一级预防侵袭性真菌病(IFD)的效果及安全性。方法:45例allo-HSCT无IFD的患者从预处理开始应用泊沙康唑,直至患者的中性粒细胞恢复至0.5×10~9/L以上为止,35例以米卡芬净预防IFD患者为对照(对照组),分析2组间IFD易感因素有无差异,比较2组IFD发生率及药物不良反应的差异。结果:移植后100 d内共有13例(16%)发生IFD,其中5例(38%)死亡,而67例未发生IFD患者中10例(15%)死亡,2组间总生存率差异有统计学意义(P=0.027)。45例泊沙康唑一级预防组中发生IFD者4例(9%),对照组中35例患者发生IFD 9例(26%),2组IFD发生率差异有统计学意义(P=0.043)。在IFD风险因素评估和不良反应评估方面,2组之间无统计学差异(P>0.05)。结论:应用泊沙康唑对allo-HSCT患者行IFD的一级预防的效果明显优于米卡芬净,且患者对治疗的耐受性良好。
Objective: To investigate the efficacy and clinical safety of posaconazoleon primary antifungal prophylaxis against invasive fungal disease (IFD) in patients with stem cell transplantation. Methods: At the start from preconditioning regimen, 45 patients without IFD were administered with posaconazoleon until neutrophils greater than 0. 5 x 109/L, 35 patients treated with micafungin were enrolled in control group. The incidence, risk factors of IFD and side effects of medicines were evaluated. Results: Of the total 80 patients, 13 (16%) had IFD within I00 days after allo-HSCT. The overall survival was significantly different between patients with or without IFD by Kaplan-Meier survival curve analysis (P 〈 0.05 ). Out of the 45 cases in posaconazoleon group, IFD occurred in 4 cases (9%). In contrast, the incidence of IFD in control group was 26% (9 out of 35 ) (P 〈 0.05 ). The risk factors of IFD and side effects were not significantly different between 2 groups ( P 〉 0.05 ). Conclusion : The primary prevention efficancy of IFD by posaconazoleon after allo-HSCT is much better than that of micafungin with well tolerability and satisfactory efficacy.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2017年第3期885-889,共5页
Journal of Experimental Hematology
关键词
泊沙康唑
侵袭性真菌病
预防效果
造血干细胞移植
posaconazole
invasive fungal disease
prevention efficancy
hematopoietic stem cell transplantation