聚丙烯酸功能化高效发光的La_(1-x)Eu_xF_3纳米晶合成及细胞成像（英文）

Synthesis of Poly(acrylic acid)-Functionalized La_(1-x)Eu_xF_3 Nanocrystals with High Photoluminescence for Cellular Imaging

采用水热合成一锅法制备了聚丙烯酸功能化单分散的La_(1-x)Eu_xF_3纳米颗粒(La_(1-x)Eu_xF_3@PAA NPs)。利用透射电子显微镜(TEM)、X射线衍射(XRD)、傅里叶变换红外光谱(FTIR)和光致发光光谱(PL)对样品的形貌、结构、组成和荧光性能进行表征。该纳米颗粒平均粒径为(7±3)nm,具有较好的分散性、稳定性与生物相容性。将纳米颗粒与He La癌细胞共同孵育,体外成像结果表明材料对He La癌细胞显示出低细胞毒性。用水热法制备的La_(1-x)Eu_xF_3@PAA纳米颗粒可以作为光学荧光探针用于细胞成像,在生物医学领域表现出巨大的潜力。

Monodisperse La1-xEuxF3 nanoparticles （NPs） were functionalized by poly（acrylic acid） （PAA） via a one-pot modified hydrothermal method. The morphology, crystal structure, surface groups, and luminescence properties of the as-produced La1-xEuxF3@PAA NPs were characterized by transmission electron microscopy （TEM）, X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR）, and photoluminescence （PL） spectroscopy. The produced nanoparticles were （7 ± 3） nm in size, water soluble and buffer stable, with good photostability and biocompatibility. In vitro imaging revealed the low cytotoxicity of the as-synthesized NPs incubated with HeLa cancer cells. Thus, the colloidal La1-xEuxF3@PAA NPs exhibit great potential for use as optical imaging probes in biological applications.