单纯型乳腺黏液癌18例临床病理特点及预后分析

Analysis of clinical pathological features and prognosis of 18 cases of pure mucinous breast cancer

目的探讨不同亚型单纯型乳腺黏液癌的临床病理特点及其对预后的影响。方法收集2006年1月至2015年8月首都医科大学附属北京世纪坛医院18例经病理检查确诊及随访信息完整的单纯乳腺黏液癌病例资料,其中A亚型15例,B亚型3例,回顾性分析两组的临床和病理特点及预后。结果 A型单纯型黏液癌的腋窝转移率为13.3%,B型为0。远处转移率A型为6.7%,B型为0;A型的ER和PR阳性率分别为93.3%和86.7%,B型的ER和PR阳性率均为33.3%;A型和B型的HER-2基因过表达率均为0;A型的Ki-67低表达和高表达率分别为80.0%和20.0%,B型分别为100.0%和0。结论单纯型黏液癌是一种预后良好的乳腺癌类型,其A亚型和B亚型具有不同的病理学特征,在生物学行为上存在差异。该分类对预后的评估意义有待进一步的研究和更多数据的支持。

Objective To study the clinical pathological features between the subtypes of the female mucinous breast cancer with its prognosis.Methods Eighteen cases confirmed as pure mucinous breast cancer （PMBC） with complete case report and follow-up information in Beijing Shijitan Hospital was collected and divided into type A PMBC and type B PMBC. A retrospective analysis was performed for both groups on clinical and pathological features and prognosis.Results The axillary metastasis rate for type A PMBC was 13.3%, and 0 for type B PMBC. The distant metastasis rate for type A was 6.7%, and 0 for type B. The percentage of ER and PR positive cases for type A was 93.3% and 86.7%, respectively, and was both 33.3% for type B. The HER-2 gene overexpression rate was both 0 for type A and B. And for Ki-67 expression, the low and high expression rate for type A was 80.0% and 20.0%, respectively, and was 100.0% and 0 for type B, respectively.Conclusions PMBC is a special subtype of the breast cancer with good prognosis. The pathological features and biological behavior between type A and type B is different. Further research and more data will be needed to access the prognosis with the classification.