放射治疗诱发体内旁效应的研究进展

Research progress on the bystander effect of radiotherapy in vivo

随着肿瘤放疗机制的不断深入研究,人们发现肿瘤放疗时引起的体内旁效应对肿瘤治疗及预后起着至关重要的作用.体内旁效应的产生主要与放疗后引起的氧化应激信号的传递、DNA损伤和免疫系统的激活相关,因此,人们可以通过干预旁效应减少放疗对正常组织损伤并提高肿瘤治疗效果.笔者就近年来放疗引起的体内旁效应及其分子机制的研究进展进行综述.

Extensive research on the mechanism of tumor radiotherapy shows that the bystander effect induced by radiation therapy in vivo plays an important role in tumor therapy and prognosis.The induction of the bystander effect is mainly related to the transmission of oxidative stress signals,DNA damage,and activation of the immune system caused by radiotherapy in vivo.Therefore,the intervention of the bystander effect could reduce injury on normal tissue and improve radiotherapy efficiency.This paper summarizes the research progress on the bystander effect of radiotherapy and its molecular mechanism in recent years in vivo.