胰肾康丸干预治疗肥胖型颈性眩晕患者临床观察

Clinical Observation of Intervention Therapy of Yishenkang Pills for Obese Patients with Cervical Vertigo

目的:观察胰肾康丸治疗肥胖型颈性眩晕患者的临床疗效。方法:将肥胖型颈性眩晕患者96例随机分为2组各48例。对照组给予饮食控制、适量锻炼、拜阿司匹林抗血小板聚集、阿托伐他汀钙调脂稳定斑块、改善脑供血(如马来酸桂哌齐特)、调控血压等治疗;治疗组在对照组治疗方案的基础上加用胰肾康丸,每天3次,每次5 g。治疗前及治疗后16周分别测定患者体质量(BW)、体质量指数(BMI)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、颈动脉内膜中层厚度(IMT)的变化。结果:治疗16周后,对照组WC、SBP及DBP均降低,与治疗前比较,差异均有统计学意义(P<0.05)。治疗组BW、BMI、WC、SBP及DBP均降低,分别与治疗前比较,差异均有统计学意义(P<0.05);且2组间比较,差异均有统计学意义(P<0.05);2组TG、TC、LDL-C及IMT均降低,而HDL-C升高,分别与治疗前比较,差异均有统计学意义(P<0.05);且2组间比较,差异均有统计学意义(P<0.05)。治疗组1例出现上腹不适合感、恶心等胃肠道反应,对症处理后,次日好转,患者无需停药。2组患者治疗前后在血常规、肝、肾功能、血糖等方面均为正常,疗效安全稳定。结论:胰肾康丸治疗肥胖型颈性眩晕患者,有协同降低BW、BMI、WC、SBP及DBP的作用,同时又能降低TC、TG、LDL-C、IMT和升高HDL-C,具有调节脑血流的作用,减少了心脑血管病的危险因素。

Objective：To observe the clinical effect of Yishenkang pills for obese patients with cervical vertigo. Methods ：Divided 96 cases of obese patients with cervical vertigo into two groups randomly, 48 cases in each group. Both groups received diet control, proper exercises, aspirin for anti-platelet aggregation, atorvastatin calcium for regulating lipid and stabilizing plaque, improvement of cerebral blood supply（such as cinepazide maleate）, blood pressure regulation and other treatment. The treatment group was additionally treated with Yishenkang pills three times a day,5 g for each time. Before treatment and after 16 weeks of treatment, determined changes of body weight（BW）, body mass index（BMI）, weight circumference（WC）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,triglyceride（TG）,total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C） and carotid intima-media thickness（IMT）.Results：After 16 weeks of treatment, comparing with those before treatment, BW, BMI,WC, SBP and DBP in the treatment group were decreased,WC,SBP and DBP in the control group were decreased,differences all being significant（P〈0.05）. Significant difference was found in the comparison between two groups（P〈0.05）. After treatment, TG, TC,LDL-C and IMT in both groups were declined, while HDL-C was increased, comparing with those before treatment,differences all being significant（P〈0.05）. The comparison between two groups showed significance in differences（P〈0.05）.There was one case of gastrointestinal reaction such as epigastric discomfort and nausea in the treatment group,but it was relieved on the next day after expectant treatment and it was unnecessary to withdraw the medicine. Before and after treatment,the blood routine,liver and renal function,blood glucose and other aspects of 96 patients were normal,and the clinical effect was safe and stable. Conclusion：The therapy of Yishenkang pills for obese patients with cervical vertigo can not only bring down BW,BMI,WC,IMT and SBP/DBP,but also decrease TC,TG and LDL-C while increase HDL-C. The therapy has the effect of regulating cerebral blood flow, which reduces the dangerous factors of cardio-cerebrovascular disease.