益气消滞汤经鼻肠管注入对食管癌术后胃肠功能恢复的影响

Effect of Yiqi Xiaozhi Tang Through Nasal-Intestinal Tube Injection on Postoperative Recovery of Gastrointestinal Function in Patients with Esophageal Carcinoma

目的:观察益气消滞汤经鼻肠管注入对食管癌术后患者胃肠功能恢复的影响。方法:将确诊为食管癌的60例患者纳入研究并随机分为2组各30例,2组患者均行手术治疗,术后即采用胃肠减压、补液、制酸护胃、抗感染等常规治疗,对照组经鼻肠管注入肠内营养混悬液,观察组经鼻肠管注入肠内营养混悬液后注入益气消滞汤。2组疗程均为3天。比较2组患者的胃肠功能恢复情况,术后第1天与术后第3天时白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)及胃肠肽(VIP)、胃动素(MOT)的水平。结果:术后第3天,2组IL-6、hs-CRP水平均较术后第1天降低(P<0.05),观察组2项指标值均低于对照组(P<0.05);2组MOT水平较术后第1天降低,VIP水平则较术后第1天升高,差异均有统计学意义(P<0.05),观察组MOT水平低于对照组,VIP水平高于对照组,差异均有统计学意义(P<0.05)。2组患者均顺利完成手术,观察组术后肛门排气时间、排便时间及肠鸣音恢复时间均短于对照组(P<0.05)。结论:益气消滞汤有助于促进食管癌术后患者的胃肠功能恢复,抑制炎症反应,调节胃肠激素水平。

Objective：To observe the effect of Yiqi Xiaozhi tang through nasal-intestinal tube injection on the postoperative recovery of gastrointestinal function in patients with esophageal carcinoma. Methods ：Selected 60 cases of patients diagnosed with esophageal carcinoma as study objects, and divided them into two groups randomly, 30 cases in each group. Both groups received operation and routine postoperative treatment, such as gastrointestinal decompression, fluid infusion,relieving hyperacidity for stomach protection and anti-infection. In addition, the control group was given intestinal nutrition solution through nasal-intestinal tube injection, the observation group was given intestinal nutrition solution through nasal-intestinal tube injection and was injected with Yiqi Xiaozhi tang. Both groups received treatment for three days.Compared the recovery of gastrointestinal function in both groups. On Day 1 and Day 3 after operation, improvements of inflammatory indexes such as interleukin-6（IL-6）,high sensitive C-reactive protein（hs-CRP） and levels of gut peptides such as vasoactive intestinal polypetide（VIP） and motilin（MOT） in two groups were compared. Recorded the curative effect,healing time and adverse drug reaction in both groups. Results： On Day 3 after operation, levels of IL-6 and hs-CRP were decreased,comparing with those on Day 1 after operation（P〈0.05）,and the indexes in the observation group were lower than those in the control group（P〈0.05）. On Day 3 after operation,comparing with those on Day 1 after operation,MOT levels in both groups were declined,while VIP levels in both groups were increased（P〈0.05）. MOT levels in the observation group were lower than those in the control group, and VIP levels in the observation group were higher than those in the control group（P〈0.05）. All patients successfully completed the operation. The time of defecation, the exhaust time and recovery time of bowel sound in the observation group after operation were all shorter than those in the control group（P〈0.05）. Conclusion：The therapy of Yiqi Xiaozhi tang through nasal-intestinal tube injection can contribute to the postoperative recovery of gastrointestinal function in patients with esophageal carcinoma,and to the inhibition of inflammatory reaction and the regulation of levels of gastrointestinal hormones.