急性ST段抬高型心肌梗死患者血清心锚重复蛋白与高敏C反应蛋白、肌酸激酶同工酶、心肌肌钙蛋白I相关性研究

Relationship between serum cardiac ankyrin repeat protein and hypersensitive C-reactive protein,creatine kinase isoenzyme MB,and cardiac troponin I in patients with acute ST elevation myocardial infarction

目的观察急性ST段抬高型心肌梗死(STEMI)患者血清心锚重复蛋白(CARP)水平变化并探究CARP水平与高敏C反应蛋白(hs-CRP)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)的相关性。方法选取确诊为急性ST段抬高型心肌梗死患者60例,在发病≤6 h、>6~12 h、>12~24 h、72 h分别抽血比较各时间段hs-CRP、CK-MB、cTnI、CARP水平变化,并采用Pearson相关分析对各时段内血清CARP水平与hs-CRP、cTnI、CK-MB的关系进行分析。结果急性STEMI患者各时间点血清hs-CRP、CK-MB、cTnI、CARP水平比较,差异均有统计学意义(F=487.534、683.673、666.447、1121.437,P均<0.05),且hs-CRP水平在发病>12~24 h和72 h均明显高于发病≤6 h及>6~12 h[(29±26)、(43±28)、(8±7)、(8±7)mg/L,P均<0.05],CK-MB水平发病≤6 h、>6~12 h、>12~24 h、72 h两两比较差异均有统计学意义[(40±16)、(124±53)、(374±98)、(108±40)μg/L,P均<0.05]。cTnI水平在发病>6~12 h、>12~24 h和72 h均明显高于发病≤6 h[(7.3±3.4)、(10.3±5.3)、(6.5±3.5)、(3.6±2.4)μg/L,P均<0.05],而CARP水平仅发病>12~24 h显著高于≤6 h、>6~12 h及72 h[(1 991±538)、(1 391±471)、(1 385±407)、(1 347±429)k U/L,P均<0.05]。Pearson相关分析发现,各时段内CARP与CK-MB均具有正相关性(P均<0.05)。结论 CARP在急性STEMI患者中明显升高,可作为急性STEMI患者辅助诊断新指标。

Objective To explore the relationship between serum cardiac ankyrin repeat protein （CARP） and hypersensitive C-reactive protein （hs-CRP）, creatine kinase isoenzyme MB （CK-MB）, and cardiac troponin I （cTnI） in patients with acute ST elevation myocardial infarction （STEMI）. Methods A total of 60 acute STEMI patients were enrolled in this study. Levels of hs-CRP, CK-MB, cTn-I and CARP were detected at ≤6 h, 〉 6-12 h, 〉 12- 24 h, 72 h after heart attack. The Pearson correlation analysis was used to analyze the relationship between the CARP levels and hs-CRP, CK-MB, cTnI at each period. Results The levels of hs-CRP, CK-MB, cTnI, and CARP were significantly different at each period （F= 487.534, 683.673, 666.447, 1121.437, all P〈0.05）. Hs-CRP at 〉12-24h and 72h were much higher than those at ≤ 6h and 〉6-12h [（29±26）, （43±28）, （8±7）, （8±7）mg/L, all P〈0.05]. CK-MB showed significant differences at ≤ 6 h, 〉 6- 12 h,〉12- 24 h, 72 h [（40 ±16）, （124± 53）, （374± 98）, （108 ± 40） μg/L, all P〈 0.05]. cTnI at 〉6-12h, 〉12-24h, and 72h were much higher than those at ≤6h after heart attack [（7.3±3.4）, （10.3±5.3）, （6.5 ±3.5）, （3.6 ± 2.4） μg / L, all P 〈 0.05]. CARP only at 〉 12-24h increased markedly as compared at ≤ 6h, 〉6-12h, 72h after heart attack [（1 991±538）, （1 391±471）, （1 385±407）, （1 347±429） kU / L, all P〈 0.05]. The Pearson correlation analysis revealed that the CARP levels at each period were positively correlated with CK-MB. Conclusion CARP increased obviously in STEMI patients and can be used as a new indicator for the diagnosis of STEMI.