胰腺纤维钙化性糖尿病一例报告及文献复习

Fibrocalculous pancreatic diabetes:A case report and literature review

回顾性分析1例胰腺纤维钙化性糖尿病(FCPD)患者的临床资料及相关文献,探讨FCPD的临床特点,提高对疾病的认识。患者男,31岁,非洲籍,无慢性胰腺炎病史及饮酒史,以急性腹痛就诊。BMI为19.1 kg/m^2,高血糖伴DKA。入院随机BG 62.94 mmol/L,HbA_1c 21.1%,FC-P 0.24μg/L、2 hC-P 0.18μg/L,胰岛自身抗体阴性。胰腺MRI显示:胰腺萎缩伴胰管明显扩张并胰管内多发结石。根据患者临床特点及辅助检查结果,考虑FCPD。良好的血糖控制是FCPD治疗的基础。

We reported a case of fibroalcul0us pancreatic diabetes （FCPD） and reviewed the related literatures to summarize the eIinical characteristics of FCPD and to improve the understanding of this disease. A 31-year-old male African patient, with no history of chronic pancreatitis and drinking history, was admitted with the onset of acute abdominal pain. On admission, the BMI was 19.1 kg/m^2. He presented with serious hyperglycemia and ketoacidosis,with the random blood glucose of 62.94 mmol/L,a glycosylated hemoglobin of 21.1%, a fasting C-peptide of 0.24 μg/L, and a postprandial C-peptide of 0.18 μg/L. Pancreatic autoantibodies were negative. Magnetic resonance imaging （MRI） showed pancreatic atrophy companied with multiple stones in expanded pancreatic duct. FCPD was diagnosed according to the patient＇s clinical features and examination results： Good glucose control is the basis of FCPD therapy.