盐酸贝尼地平治疗冠状动脉慢血流型心绞痛效果评价

Curative effect of benidipine hydrochloride on patients with coronary slow flow angina pectoris

目的 评价盐酸贝尼地平对冠状动脉慢血流型心绞痛（CSFA）的临床治疗效果.方法 60例CSFA患者随机分为治疗组及对照组各30例;对照组予口服阿司匹林（100 mg,1次/d）及阿托伐他汀（20 mg,1次/d）治疗,治疗组在此基础治疗上加用盐酸贝尼地平（4 mg,1次/d）治疗.随访6个月,比较两组患者的临床治疗有效率（心绞痛缓解及心电图的心肌缺血表现减轻）、治疗前后校正的心肌梗死溶栓治疗（TIMI）血流帧数（CTFC）及心血管不良事件发生率.结果 治疗组的治疗有效率86.7%（26/30）高于对照组63.3%（19/30）,差异有统计学意义（χ^2=4.356,P=0.037）;两组治疗后CTFC均较治疗前减少,差异有统计学意义[治疗组 ：（28.43±3.95）帧 与（18.40±3.73）帧,t=10.254,P=0.000;对照组：（27.87±4.14）帧与（21.87±4.17）帧,t=5.580,P=0.000];且治疗组较对照组治疗后CTFC减少更为显著,差异有统计学意义（t=2.138,P=0.037）;治疗组的心血管不良事件发生率10.0%（3/30）低于对照组33.3%（10/30）,差异有统计学意义（P=0.028）.结论 盐酸贝尼地平可有效治疗冠状动脉慢血流型心绞痛.

Objective To investigate the curative effect of benidipine hydrochloride on patients with coronary slow flow angina pectoris（CSFA）.Methods Sixty cases patients with CSFA were randomly divided into two groups of 30 patients each.In the control group patients were received aspirin（100 mg,1 times/d） and atorvastatin（20 mg,1 times/d） as basic treatment;in the treatment group patients were received basic treatment plus benidipine hydrochloride（4 mg,1 times/d）.Follow up for 6 mouths,the effectiveness rate of treatment（relief of angina and electrocardiogram of myocardial ischemia）,the correction of thrombolysis in myocardial infarction（TIMI） frame count（CTFC） before and after the different intervention,and the incidence of adverse cardiovascular events were compared between the treatment group and the control group.Results The effectiveness rate of treatment in the treatment group（86.7%,26/30） was significantly higher than that in the control group（63.3%（19/30）;χ2=4.356,P=0.037）.There were significant reductions of CTFC in both groups after the different intervention（treatment group：（28.43±3.95） frames vs.（18.40±3.73） frames,t=10.254,P=0.000;control group：（27.87±4.14） frames vs.（21.87±4.17） frames,t=5.580,P=0.000）.There was more significant reductions of CTFC in the treatment group as compared to the control group（t=2.138,P=0.037）.The incidence of adverse cardiovascular events in the treatment group（10.0%（3/30）） was significantly lower than that in the control group（33.3%（10/30）,P=0.028）.Conclusion Benidipine hydrochloride is effective in the treatment of CSFA.