4-(3-哌啶基)苯胺及其酒石酸盐的制备方法

The Preparation of 4-(piperidin-3-yl) aniline and Its Tartrate

4-(3-哌啶基)苯胺是PARP抑制剂尼拉帕尼的重要合成中间体。本文以对硝基苯乙酸为原料,通过酯化、Michael加成、还原,最终成盐合成了4-(3-哌啶基)苯胺及其酒石酸盐,该方法原料易得,成本低廉,操作简单。

4-（Piperidin-3-yl）anitine isan important synthetic intermediate for Niraparib, a PARP inhibitor. A novel synthesis for it has been developed with p-nitrophenylacetic acid as starting material, which includesesterification, Michael addition, reduction and salt formation.The method has convenient and economic advantages.