雷西纳德类似物的设计与合成

Synthesis and Design of Lesinurad Analogues

为了寻找新的尿酸转运蛋白1(URAT1)抑制剂,本文在对雷西纳德及其相关药物结构研究的基础上,运用了生物电子等排原理和前药原理,以4-(4-环丙基萘-1-基)-4H-1,2,4-三唑-3-硫醇为原料设计合成了5个雷西纳德类似物,均未见文献报道,目标化合物结构均经1H-NMR和ESI-MS确证。

In order to find some new URAT1 inhibitors, using Biological Electronic principle and Prodrug principle ,we have designed and synthesized 5 analogues of lesinurad that have not reported on the basis of 4-（4-cyclopropylnaphthalen-l-yl）-4H-1,2,4-triazole-3-thiol. The structures of all target compounds were idantifined by 1H-NMR and ESI-MS.