血清游离脂肪酸与非胰岛素依赖型糖尿病代谢异常关系探讨

Relationship between serum free fatty acid and non-insulin-dependent diabetes mellitus metabolic disorder

目的探讨血清游离脂肪酸(FFA)与非胰岛素依赖型糖尿病(NIDDM)代谢的关系。方法检测625例NIDDM患者、283名健康体检者(正常对照组)血脂{游离脂肪酸(FFA)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(apo A1)、载脂蛋白B100(apo B100)、脂蛋白(a)[Lp(a)]}、同型半胱氨酸(Hcy)、血糖(Glu)、糖化血红蛋白(HbA1c)、尿酸(UA)、肌酐(Cr)、尿素、胱抑素C(Cys C)及丙氨酸氨基转移酶(ALT)水平。将NIDDM患者按病情分为初发病组(47例)、病情稳定组(545例)及病情不稳定组(33例),对各组检测结果进行比较。结果初发病组各项指标检测结果与正常对照组比较,差异均有统计学意义(P<0.05);病情不稳定组FFA、Lp(a)、apo A1、apo B100、LDL-C、HDL-C、Glu、ALT、HbA1c及UA与正常对照组比较,差异均有统计学意义(P<0.01),病情稳定组HDL-C、apo A1、LDL-C、apo B100、FFA、Lp(a)、Glu、ALT、HbA1c、UA与正常对照组比较,差异均有统计学意义(P<0.05),其他指标检测结果2个组间差异无统计学意义(P>0.05)。结论 NIDDM患者FFA及血脂水平与其代谢异常有一定的关系。

Objective To investigate the relationship between serum free fatty acid（FFA）and non-insulin-dependent diabetes mellitus（NIDDM） metabolic disorder.Methods A total of 625 patients with NIDDM and 283 healthy subjects were enrolled,and serum FFA,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein（apo） A1,apo B100,lipoprotein [Lp（a）],homocysteine（Hcy）,glucose（Glu）,glycated hemoglobin A1c （HbA1c）,uric acid（UA）,creatinine（Cr）,urea,cystatin C（Cys C）and alanine aminotransferase（ALT） were determined. NIDDM patients were classified into new-diagnosed NIDDM group（47 cases）,stable group（545 cases） and unstable group（33 cases）.Results There was statistical significance for these parameters between newly-diagnosed NIDDM and healthy control groups（P〈0.05）. There was statistical significance for FFA,Lp （a）,apo A1,apo B100,LDL-C,HDL-C,Glu,ALT,HbA1c and UA between unstable and healthy control groups（P〈0.01）. There was statistical significance for HDL-C,apo A1,LDL-C,apo B100,FFA,Lp（a）, Glu,ALT,HbA1c and UA between stable and healthy control groups（P〈0.05）,and there was no statistical significance for other parameters compared with healthy control group（P〉0.05）.Conclusions The levels of FFA and blood lipid in NIDDM patients have a correlation with metabolic disorder.