热熔法制备聚己内酯基温敏性药物释放体系及其释药性能

Poly(ε-caprolactone)Based Thermo-Sensitive Drug Release Systems Prepared Through Melt Blending

以聚己内酯(PCL)和甘油三月桂酸酯(C12)为基体,双氯芬酸钠(DS)为模型药物,熔融共混制备了一种温敏性药物释放体系。通过差示扫描量热分析和扫描电子显微镜对共混物形态结构进行了表征,采用亲水接触角探讨了C12的加入对材料亲水性的影响。结果表明,C12的加入能在37℃条件下有效减缓药物突释,而在45℃时,由于C12熔点较低会发生相变,使体系得以迅速释放药物,具有良好的高温响应释药性能。通过不同温度的拉伸性能测试可知,在加入C12后,共混物仍能在不同温度下保持一定的力学强度。

Poly（ε-caprolactone） （PCL） based thermo-sensitive drug release system was prepared through melt blending, using glyceryl trilaurate （C12） as thermo-responsive material. Diclofenac sodium （DS） was used as a model drug. Differential scanning calorimetry （DSC）, scanning electron microscope （SEM） and water contact angle of the materials were performed to investigate the influence of C12 on the morphological properties of PCL/C12 blends. It is indicated that the addition of C12 improves the dispersion of DS, and adjusts the hydrophilic property of the blends. Due to the hydrophobicity of C12, the DS release of PCL/C12 blends is lower than that of pure PCL at 37 ℃. While at higher temperature （45 ℃）, C12 is partially melted due to its low melting point （48.2 ℃）, which can improve the permeability of PBS buffer solution into the matrices, leading to a higher drug release of DS. As a result, the PCL/C12 blends exhibit a thermo-responsive DS release behavior, with the mechanical strength of the materials maintained.