蒙药红珊瑚的化学成分研究

Chemical Constituents of Red Coral

通过研究红珊瑚的化学成分,为寻找其活性成分提供基础。应用GC-MS、Sephadex LH-20、HPLC等方法进行分析与分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定。并利用电感耦合等离子体质谱仪分析方法对13种无机元素进行含量测定。结果表明:从红珊瑚脂溶性成分中分析出16种化合物,含有烷烃类、脂类、醇类、角鲨烷、鲨烯等有机化合物,其中12个化合物为首次从红珊瑚脂溶性成分中分析得到;分离、鉴定出5个化合物,分别为邻苯二甲酸异丁酯、邻苯二甲酸正丁酯、咔唑、对羟基苯甲酸、6(5H)-菲啶酮,均为首次从红珊瑚中分离得到;红珊瑚含有6%左右的钙,富含镁、钠、铁、钾、锌等无机元素。

To study the chemical components and determination of inorganic element content of red corM, the chemical constituents were isolated and purified by silica gel, Sephadex LH-20 and HPLC chromatography. The structures of the isolated compounds were elucidated by spectroscopic analysis and physicochemical properties. The content of thirteen elements in red coral was analyzed by the ICP-MS method. The results showed that 16 kinds of compounds were obtained from the Red coral li- posoluble component that contained alkane, lipid, alcohols, squalane, and other organic compounds, among them there are 12 substances reported for the first time; Five compounds were first obtained from red coral and identified as diisobutyl phthMate, dibutyl phthalate, carhazole, p-hydroxy benzoic acid, 6 （5 H）-Phenanthridinone from this coral; there are about 6% calcium in the red coral, and magnesium, sodium, iron, potassium, zinc and other mineral elements are also rich in content.