盐酸氨溴索与溴己新治疗急性发作期慢性阻塞性肺疾病的疗效观察

Efficacy of ambroxol hydrochloride and bromhexine in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的探讨盐酸氨溴索与溴己新在治疗急性发作期慢性阻塞性肺疾病(COPD)的疗效。方法收集我院88例COPD急性发作期患者,随机分为两组,各44例。两组患者均给予相同的对症支持治疗,试验组患者给予盐酸氨溴索治疗,对照组患者给予溴己新治疗。记录两组患者的治疗总有效率、治疗前后两组患者的呼吸频率、氧饱和度及用力肺活量。结果试验组患者治疗总有效率高于对照组(P<0.05)。治疗后,试验组患者氧饱和度、呼吸频率及用力肺活量明显优于对照组患者(P<0.05)。结论盐酸氨溴索治疗COPD急性发作期患者优于溴己新,有效率更高,安全性较高。

Objective To investigate the efficacy of ambroxol hy drochloride and bromhexine in the treatment of acute exacerbation of chronic obstructive pulmonary disease （COPD）. Methods A total of 88 patients with acute exacerbation of COPD in our hospital were enrolled and divided into two groups, with 44 cases in each group. Both groups were given the same symptomatic and supportive treatment. The experimental group was treated with ambroxol hydrochloride, and the control group received bromhexidine. The total effective rate of the treatment, respiratory rate, oxygen saturation and forced vital capacity before and after treatment were analyzed. Results The effective rate of the experimental group was higher than that of the control group （P〈0.05）. After treatment, the oxygen saturation, respiratory rate and forced vital capacity of the experimental group were significantly better than those of the control group （P〈0.05）. Conclusion Ambroxol hydrochloride has better efficacy compared wish bromhexine in treating patients with acute exacerbation of COPD, with more efficient and high security.