脑卒中与同型半胱氨酸的相关性研究

Association of homocysteine with cerebral stroke

目的探讨脑卒中与同型半胱氨酸(Hcy)的相关性。方法选择200例脑卒中患者和200名健康对照组,测定Hcy进行比较,并根据梗死面积和病程进行分类。结果大梗死组、小梗死组、腔隙梗死组的Hcy平均水平明显高于对照组,差异均有统计学意义(P<0.05),Hcy水平与脑卒中患者梗死面积呈正相关(r=0.38,P=0.004)。急性期组、亚急性期组、慢性期组脑卒中患者平均Hcy水平较对照组平均Hcy水平明显增高,差异均有统计学意义(P<0.05),Hcy水平与脑卒中患者病程严重程度呈正相关(r=0.43,P=0.006)。结论 Hcy水平与脑卒中患者发病有关,有助于脑卒中的诊断与监测。

Objective To discuss the association of homocysteine （Hcy） with cerebral stroke. Methods Two hundred stroke inpatients and 200 healthy people as the control were selected and detected. The detection results were compared. 200 stroke inpatients were classified according to the infarct size and the progress of disease in stroke. Results Compared with the control group, the Hey in infarct group of big size, small size and lacunar were apparently higher and had statistical differences （P〈0.05）. The Hcy level was positively related to the infarct size （r=0.38, P=0.004）. Compared with the control group,the Hey in the acute stage, subacute stage and chronic stage groups were apparently higher and had statistical differences （P〈0.05）. The Hey level was positively related to the severity level of the progress of disease （r=0.43, P=0.006）. Conclusion Homoeysteine is related with occurrence of stroke, which is useful to diagnose and monitor stroke.