不同剂量静注人免疫球蛋白对新生儿防治感染的效果观察

Observation on Curative Effects of Different Volumes of Human Immunoglobulin for Intravenous Injection in Preventing Newborn from Infection

目的观察比较不同剂量静注人免疫球蛋白对新生儿防治感染的效果。方法将104例新生儿肺炎患儿随机分为观察组和对照组,每组52例。在常规治疗基础上,对照组静脉滴注免疫球蛋白,剂量为1.25g/次,给药1次;观察组静脉滴注免疫球蛋白,剂量为2.5g/次,给药1-2次。比较两组新生儿肺炎症状消失时间、肺部湿啰音消失时间、疗程,并比较两组临床治疗有效率。结果观察组治疗有效率为94.2%明显大于对照组的73.1%(P<0.05)。观察组较对照组肺炎症状消失时间、肺部湿啰音消失时间及疗程均明显缩短(P<0.05)。结论静脉注射大剂量免疫球蛋白可促进新生儿肺炎患儿症状快速消失,提高治疗有效率,值得临床推广。

Objective To observe and compare the curative effects of different volumes of human immunoglobulin for intravenous injection in preventing newborn from infection. Methods 104 cases of pneumonia newborn were randomly divided into observation group and contrast group with each group 52 cases, on the basis of conventional treatment, the newborn in the contrast group were given human immunoglobulin for intravenous injection of 1.25g per time and 1 time per day, while the newborn in the observation group were given human immunoglobulin for intravenous injection of 2.5g per time and 1-2 times per day. Observe and compare the newborn pneumonia symptoms extinction time, the lung rale extinction time, course of treatment and the total effective rate of therapy. Results the total effective rate in the observation group （94.2%） was obviously higher than the contrast group （73.1%）. The difference showed a statistical significance （P〈0.05）. The newborn pneumonia symptoms extinction time, the lung rale extinction time and the course of treatment in the observation group was all significantly shorter than those in the contrast group. The difference showed a statistical significance （P〈0.05）. Conclusion Large volume of human immunoglobulin for intravenous injection is proved to be effective in promoting pneumonia symptoms extinction and improve the total effective rate. Thus, it deserves to be widely promoted in the clinical field.