摘要
Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ-
Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting; however, clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported [1 ]. Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug; these patients presented with the typical characteristics of idiosyncratic drug-induced liver injury （IDILI）. Human IDILI can be reproduced in animals by drug coexposure to appropriate doses of lipopolysaccharide （LPS）, which evokes modest inflammatory stress [2]. Many drugs that cause human IDILI, including ranitidine [3] and trovafloxacin [4], can also cause liver injury with a non-hepatotoxic dose in the LPS model.
基金
supported by the National Natural Science Foundation of China(81503350)
the National Key Technology R&D Program(2015ZX09501-004-001-008)
the National TCM Industry Science and Technology Program(201507004-04)
the Open Research Fund of State Key Laboratory Breeding Base of Systematic research,Development and Utilization of Chinese Medicine Resources and China Postdoctoral Science Foundation(2016M590065)
