摘要
目的:探讨艾司西酞普兰治疗伴焦虑症状抑郁症的疗效和安全性。方法:101例伴焦虑症状的抑郁症患者随机分为研究组50例(艾司西酞普兰治疗)和对照组51例(帕罗西汀治疗),疗程6周。采用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效,采用副反应量表(TESS)评估不良反应。结果:研究组和对照组的有效率分别为89.9%和81.5%(P<0.05),临床治愈率分别为66%和51%(P<0.05);治疗后1周、2周、4周、6周研究组HAMD、HAMA评分均显著低于对照组(P<0.05);研究组心悸、恶心、头晕三项不良反应发生率均低于对照组(P<0.05)。结论:艾司西酞普兰对伴焦虑症状的抑郁症疗效优于帕罗西汀,起效更快,不良反应更少。
Objective: To investigate the efficacy and safety of Escitalopram in treatment of major depressive disorder with anxiety. Methods: A total of 101 depression patients with anxiety were randomized to study group with Escitalopram or control group with Paroxetine for 6 weeks. The changes in total score of the Hamilton Depression Scale 17 item (HAMD17) and Hamilton Rating Scale for Aniety (HAMA) were used to evaluate the therapeutic effect in treatment. Treatment Emergent Symptom Scale (TESS) was used to evaluate the adverse effect. Results:The response rates of the two groups were 89.9% (study group) and 81.5% (control group) (P〈0.05),while the clinical cure rates were 66% ( study group) and 51% (control group) (P〈0.05). The score of HAMD and HAMA in study group were significantly lower than those of control group after treatment for 1 week, 2 weeks,4 weeks and 6 weeks respectively (P〈0.01). The adverse reactions including nausea, palpitation and giddiness in study group were significantly lower than those in controlled group (P〈0. 05). Conclusion: In the treatment of depression with anxiety, Escitalopram is more effective with lesser adverse reactions rate compared with paroxetine.
出处
《医学理论与实践》
2017年第11期1568-1569,1572,共3页
The Journal of Medical Theory and Practice
关键词
伴焦虑抑郁症
艾司西酞普兰
帕罗西汀
疗效
Depression associated with anxiety, Escitalopram,Paroxetine, Efficacy