脑梗死急性期情感淡漠与同型半胱氨酸相关性研究

Relationship between Apathy and Homocysteine in Patients with Acute Cerebral Infarction

目的:探讨脑梗死患者急性期情感淡漠发生率及其与同型半胱氨酸(Hcy)的相关性。方法:连续收集我院神经内科脑梗死患者109例,发病2周时采用修订情感淡漠量表(MAES)进行评分,分为情感淡漠组与非情感淡漠组,采用循环酶法检测血Hcy,比较2组间血Hcy水平及相关因素的差异,并将Hcy与MAES评分进行秩相关分析。结果:脑梗死患者急性期情感淡漠发生率为33.9%(37例),情感淡漠组Hcy水平高于非情感淡漠组(P<0.05),Hcy水平与MAES评分呈正相关(r=0.713,P<0.05)。结论:脑梗死患者急性期情感淡漠发病率较高,Hcy在脑梗死后情感淡漠发展过程中可能起着重要作用。

Objective： To investigate the incidence of apathy and its correlation with homocysteme m panenrs witn acute cerebral infarction. Methods： A total of 109 patients with acute cerebral infarction were selected in clinical practice. Based on the Modified Apathy Evaluation Sacle （MAES）, all patients were divided into two groups： apathy group and non apathy group. The serum homocysteine level was measured by enzymatic cycling method. Differences in the homocysteine and other related factors were compared in the two groups, and correlation analysis was used to estimate the correlation between homoeysteine and apathy. Results：The incidence of apathy among 109 patients was 33.9%o （37 ca- ses）. Serum homocysteine was higher in apathy group than in non apathy group （P〈0. 05）. Homocysteine level was positively correlated with MAES score （r= 0. 713, P〈0. 05）. Conclusion： The incidence of apathy in patients with acute cerebral infarction was relatively high, and homoeysteine may play an important role in the development of apathy after cerebral infarction.