血浆置换术联合糖皮质激素应用对乙型肝炎病毒所致早期肝衰竭患者的临床观察

The Clinical Effect of Plasma Exchange Technology and Glucocorticoid for HBV Infected Patients with Early Liver Failure

目的:探讨血浆置换术联合糖皮质激素应用对乙型肝炎病毒所致早期肝衰竭患者的治疗疗效。方法:选取120例乙型肝炎病毒所致早期肝衰竭患者为观察对象,随机分为观察组(n=60)和对照组(n=60),观察组在常规综合治疗基础上使用血浆置换术联合糖皮质激素治疗,对照组则在常规综合治疗基础上使用血浆置换术治疗,观察两组患者的治疗疗效。结果:治疗4周后两组患者在乏力、纳差等消化道症状、ALT、HBV-DNA以及并发症的发生上差异无统计学意义(P>0.05);观察组的TBIL、ALB、PT、PTA有明显改善,治疗好转率高于对照组,差异均有统计学意义(P<0.05)。结论:应用血浆置换术联合糖皮质激素治疗乙型肝炎病毒所致早期肝衰竭患者有一定疗效。

Objective： To explore the functions of plasma exchange technology and glucocorticoid for hepatitis B infected patients with early liver failure. Methods： 120 patients with early stage of hepatitis B related liver failure were selected as subjects, were randomly divided into observation group（n = 60）and control group（n = 60）. Based on conventional therapy, the observation group received plasma exchange technology and glucocortieoid. While the control group only received plasma exchange technology. The clinical efficacy between two groups were observed. Results： After 4 weeks treatment,there is no statistical significance in physical fatigue, poor appetite, digestive tract symptoms, ALT, HBV- DNA and the occurrence of complications（P〉0. 05）. There is significant improvement in the TBIL, ALB, PT and PTA of the observation group, the improvement rate was significantly higher in ovservation group than that in control group, statistical significance in the differences （P 〈 0. 05）. Conclusion.. Plasma exchange technology and glucocorticoid can work well on hepatitis B infected patients with early liver failure.