肿瘤标志物在肺癌检验中的临床应用

Study of tumor markers in lung cancer clinical application of inspection

目的探讨肿瘤标志物检测对肺癌的诊断意义。方法采用随机抽样方法选取2015年2月至2016年3月陕西省西安市灞桥区唐都医院收治的肺癌患者70例作为研究组，再随机选取该阶段收治的良性肺部疾病患者70例作为对照组，最后选取该阶段进行健康体检者70例作为健康对照组。3组研究对象均需实施肿瘤标志物检查，然后统计比较3组研究对象及患者治疗前后肿瘤标志物检测情况。结果研究组患者治疗前肿瘤标志物中的癌抗原125（CAl25）、癌胚抗原（CEA）及神经元特异性烯醇化酶（NSE）等指标均明显高于健康对照组、对照组，治疗后各肿瘤标志物水平均明显低于治疗前，差异均有统计学意义（P〈0．05）；检测CAl25的灵敏度为42．86％（30／70），CEA的灵敏度为44．29％（31／70），NSE的灵敏度为21．43％（15／70），糖链抗原199（CAl99）的灵敏度为24．29％（17／70），细胞角蛋白i9片段的灵敏度为55．71％（39／70），而联合检测上述5种肿瘤标志物的灵敏度为82．86％（58／70），差异均有统计学意义（P〈0．05）。结论检测肿瘤标志物能用于肺癌的诊断，且联合检测的灵敏度显著增加。

Objective To investigate the diagnostic value of tumor markers in the diagnosis of lung cancer. Methods 70 cases of lung cancer patients were randomly selected from February 2015 to March 2016 in hospital as study group, 70 cases of benign lung dis-ease patients were randomly selected as the control group,and 70 cases of healthy people were selected as the health group. Three groups of patients are required to implement tumor markers,and then counted and compared of the three groups of patients before treatment and after treatment of tumor markers. Results Before treatment,the patients of study group with tumor markers carbo- hydrate antigen 125 ,carcinoembryonic antigen and neuron specific enolase were significantly higher than the healthy group and the control group（P〈0.05）. The level of tumor markers in study group after treatment was significantly lower than that before treat- ment, the difference was significant（P〈0.05）. The sensitivity of carbohydrate antigen 125 was 42.86 % （30/70）, the sensitivity of earcinoembryonic antigen was 44.29% （31/70）,the sensitivity of neuron specific enolase was 21.43% （15/70）,the sensitivity of CA199 was 24.29%（17/70）, the sensitivity of cytokeratin 19 fragment was 55.71% （39/70） ,and sensitivity of combined detection the five tumor markers was 82.86%（58/70）（P〈0.05）. Conclusion The detection of tumor markers can be used for the diagnosis of lung cancer,and the sensitivity of combined detection is significantly increased.