双向转诊发现的CIN与HPV分型感染的相关性

Study on the Relationship between the Cervical Intraepithelial Neoplasia and Type of Human Papilloma Virus in Two Way Referral

目的研究上海市闵行区免费HPV筛查阳性对象中宫颈上皮内瘤变(CIN)临床分级与HPV分型感染的相关性。方法回顾性分析闵行区2015年1月—2016年9月免费HPV筛查阳性并通过区内双向转诊发现的CIN患者169例,其中CINⅠ级组74例,CIN Ⅱ级组42例,CIN Ⅲ级组53例,研究闵行区CIN与HPV分型感染的相关性。结果不同级别CIN中,均以16、58、52和18型占据前四位,CINⅠ、CINⅡ和CINⅢ三组的HPV16型感染率分别为26.04%、25.49%和38.03%,CINⅢ组较其他两组显著升高,具有统计学意义(P<0.05)。结论三组CIN临床分级和HPV感染存在相关性,均以16、58型感染最显著,可以将HPV分型检测作为判断CIN临床分级和宫颈癌病变程度的重要参考依据。

OBJECTIVE To analyze the relationship between the cancer degrees of cervical intraepithelial neoplasia（CIN） and the typesof human papilloma virus（HPV） among the positive participants during HPV screening tests in Minhang District. METHOD Patientswith CIN were regarded as targeted participants whose HPV screening test results were collected from Jan. 2015 to Sep. 2016 retro-spectively,in which 74 of CIN-Ⅰ,42 of CIN-Ⅱ and 53 of CIN-Ⅲ. RESULTS Among the different CIN degree patients, high-risk-16,58,52,18 were ranked as the top 4 types of HPV infected. High-risk-16 type of HPV infected was 26.04%,25.49% and38.03% among these three CIN groups,respectively. There were more patients with high-risk-16 type of HPV infected among the CIN-3 group significantly. CONCLUSION There were positive relationships between CIN cancer degrees and the high-risk-16 andthe high-risk 58 type of hpv infected. HPV screening test results could be used as the predictors of CIN cancer degree.