臭氧注射联合电热针治疗膝骨关节炎随机对照研究

A Randomized Controlled Trial of Ozone Injection plus Electrothermal Acupuncture for Treatment of Knee Osteoarthritis

目的比较臭氧注射联合电热针和口服氨基葡萄糖及尼美舒利治疗膝骨关节炎的疗效。观察两种疗法对WOMAC评分及疼痛积分、僵硬积分、膝关节功能积分的影响。方法将80例膝骨关节炎患者随机分为联合组和西药组,每组40例。联合组采用臭氧关节腔注射和电热针联合疗法,西药组口服盐酸氨基葡萄糖和尼美舒利缓释片。治疗前后对患者进行WOMAC量表评分,利用WOMAC评分进行疗效评价。结果臭氧注射联合电热针治疗膝骨关节炎在控显率上优于西药组。两组患者治疗后WOMAC均降低(P<0.05),联合组评分降低程度大于西药组(P<0.05)。联合组在疼痛积分、僵硬积分的下降上与西药组无明显差异(P>0.05),在膝关节功能积分上联合组下降大于西药组(P<0.05)。结论臭氧联合电热针治疗膝骨关节炎较西药治疗效果更好,其对疼痛和关节僵硬的改善与西药组无明显差异,但对膝关节功能的改善更好。

Objective To compare the efficacy of ozone injection plus electrothermal acupuncture versus oral glucosamine and nimesulide in treating knee osteoarthritis and investigate the effects of the two treatments on the WOMAC total score and the pain, stiffness and physical function scores. Method Eighty patients with knee osteoarthritis were randomly allocated to combination and Western medicine groups, 40 cases each. The combination group received a combined treatment with intra-articular ozone injection and electrothermal acupuncture and the Western medicine group took glucosamine hydrochloride and nimesulide sustained-release tablets. The WOMAC score was recorded in the patients before and after treatment. The therapeutic effects were evaluated using the WOMAC score. Result The control and marked efficacy rate of ozone injection plus electrothermal acupuncture for knee osteoarthritis was higher than that of Western medicine. The WOMAC score decreased in both groups after treatment （P〈0.05） but decreased more in the combination group than in the Western medicine group （P〈0.05）. There were no significant post-treatment differences in the pain and stiffness scores between the combination and Western medicine groups （P〉 0.05）. The physical function score decreased more in the combination group than in the Western medicine group （P〈 0.05）. Conclusion Ozone injection plus electrothermal acupuncture is more effective than Western medicine in treating knee osteoarthritis. It is more effective in improving knee function but not in relieving the pain and joint stiffness in comparison with Western medicine.