摘要
利用紫外-可见吸收光谱法研究了六、七、八元瓜环与芦丁的相互作用以及p H对其作用的影响,考察了包合物的体外缓释性能。结果表明,六、七元瓜环可以与芦丁形成1∶1的主客体包结物,八元瓜环与芦丁形成1∶2的包结物。包结平衡常数分别为3.6×10~5L·mol^(-1)、2.1×105L·mol^(-1)、1.9×10^(10)L^2·mol^(-2)。芦丁原药,Q[6]-芦丁、Q[7]-芦丁、Q[8]-芦丁包结物在人工胃液(p H=1.2)中60 min内的累计释放度分别为60.19%、46.71%、49.57、32.54%,在人工肠液(p H=6.8)中的累计释放度分别为73.76%、48.58%、51.32%、33.58%,且缓释曲线非常相似。实验结果表明,瓜环-芦丁主客体包结物的体外累积释放度明显低于芦丁原药,瓜环Q(n=6、7、8)对芦丁均有明显的体外缓释作用,且Q[8]对芦丁的缓释效果最为显著。
The host-gust interaction between cucurbit[n]urils( Q[n],n = 6,7,8]) and rutin from flavones in wet Jiub was investigated by using UV-vis spectroscopy in solution.The effect of p H on the interaction and the slow release properties of host-gust inclusion complexes were observed by UV-vis spectroscopy.The results related that a 1: 1 host to guest complex were formed between Q[n= 6,7]and rutin,however,the Q[8]include rutin with a 1 ∶ 2 ratio.The stability constants of inclusion are 3. 6×10^5L·mol^-1,2. 1×10~5L·mol^-1,1. 9×10^10L^2·mol^-2for Q[6]-rutin,Q[7]-rutin and Q[8]-rutin systems respectively. The cumulative release rate in rutin,Q[6]-rutin,Q[7]-rutin and Q[8]-rutin in artificial gastric juice( p H = 1. 2) at 60 min were 60. 19%,46. 71%,49. 57,32. 54%respectively,and in artificial intestinal fluid( p H = 6. 8) at 60 min were found to be 73. 76%,48. 58%,51. 32%,33. 58% respectively,and the curves of slow release were similarity.The experimental results show that the cumulative release rate of host-gust complex were obviously slower than rutin.The slow release property of cucurbit[n]urils( Q[n],n = 6,7,8]) to rutin were obviously,and Q[8]to rutin the slow release effect is remarkable especially.
出处
《化学研究与应用》
CSCD
北大核心
2017年第6期799-804,共6页
Chemical Research and Application
基金
贵州省卫生厅校科技联合基金项目(Gzwkj2012-2-018)资助
黔南民族医学高等专科学校基金项目(QNYZ201510)资助
黔南州科技计划项目(黔南州科合社字(2015)2号)资助
关键词
瓜环
乌纠
芦丁
缓释性
主客体相互作用
cucurbit[n]uril
wet jiub
Rutin
slow release property
interaction of host-gust