机械通气对ICU肺动脉高压伴呼吸衰竭患者血浆脑钠肽水平的影响

Effect of Mechanical Ventilation on Plasma Brain Natriuretic Peptide Level in ICU Patients with Pulmonary Hypertension Complicated with Respiratory Failure

目的探讨机械通气对ICU肺动脉高压伴呼吸衰竭患者血浆脑钠肽水平的影响。方法随机抽取86例ICU肺动脉高压伴呼吸衰竭患者分为两组,观察组43例患者应用面罩呼吸机予以辅助呼吸治疗,对照组43例患者行气管插管呼吸机辅助治疗,并对两组患者治疗前后脑钠肽、肺动脉压水平以及并发症发生率进行比较分析。结果治疗后,观察组脑钠肽、肺动脉压力均高于对照组(均P<0.01);观察组并发症发生率为6.98%,低于对照组的23.26%(P<0.05)。结论 ICU肺动脉高压伴呼吸衰竭患者行气管插管机械通气治疗的临床效果肯定。

Objective To investigate the effect of mechanical ventilation on plasma brain natriuretic peptide （BNP） level in patients with ICU pulmonary hypertension and respiratory failure.Methods Eighty-six patients with ICU pulmonary hypertension and respiratory failure were randomly divided into treatment group（n=43） and control group（n=43） with tracheal intubation and ventilator.Group before and after treatment of patients with brain natriuretic peptide,pulmonary artery pressure levels and the incidence of complications.Results After treatment,the levels of brain natriuretic peptide and pulmonary artery pressure in the study group were higher than those in the control group（allP〈0.01）;the complication rate in the study group was 6.98%,lower than 23.26% in the control group）.Conclusion The clinical effect of endotracheal intubation mechanical ventilation in patients with ICU pulmonary hypertension and respiratory failure is certain and can be used for reference.