分子吸附再循环系统治疗肝功能衰竭合并肝性脑病的临床效果观察

Objective to investigate the clinical effect of molecular adsorbent recirculating system in the treatment of hepatic failure complicated with hepatic encephalopathy

目的探讨分子吸附再循环系统在肝功能衰竭合并肝性脑病治疗中的临床应用效果。方法将我院2015年1月~2016年1月收治的肝功能衰竭合并肝性脑病患者100例,根据治疗方式的不同分为观察组和对照组,每组50例。对照组50例患者接受保肝、维持水电解质平衡以及营养支持等综合治疗,观察组50例患者在综合治疗基础之上接受分子吸附再循环系统治疗,并对两组患者的治疗效果,治疗前后肝功能改善情况、不良反应进行统计分析。结果两组患者治疗前的总胆红素、凝血酶原活动度、血氨以及Glasgow昏迷评分比较差异无统计学意义(P>0.05)。观察组患者治疗3天后的总胆红素以及血氨明显低于对照组,两组比较差异有统计学意义(P<0.05);而且治疗有效率明显高于对照组(P<0.05),治疗后肝性脑病清醒率高于对照组(P<0.05)。两组患者治疗期间均无严重不良反应。结论肝功能衰竭合并肝性脑病患者在综合治疗上采取分子吸附再循环系统治疗的效果显著,可明显改善患者肝功能,提高肝性脑病清醒率,且不良反应少,值得临床推广使用。

Objective To study the method and therapeutic effect of molecular adsorbent recirculating system in the treatment of hepatic failure complicated with hepatic encephalopathy.Methods A retrospective analysis of our hospital from January 2015 to January 2016 from complications of hepatic encephalopathy in patients with 100 cases,100 cases according to the different treatment of the selected patients were divided into two groups,50 cases each,the control group of 50 patients received liver protection,maintenance of water electrolyte balance and nutritional support comprehensive treatment,study group of 50 patients received the treatment of molecular adsorbent recirculating system on the basis of comprehensive treatment,study group and control group patients,liver function after statistical study group and control group patients before treatment and treatment to improve the situation and adverse reactions,the resulting numerical statistical analysis.Results The results of the study group and the control group of patients before treatment,total bilirubin prothrombin activity,blood ammonia and glasgow coma score comparison was not statistically significant （P〉0.05）;patients in the treatment group total bilirubin after 3 days,blood ammonia was significantly lower than control group,two groups of than there were significant differences （P〈0.05）;the study group patients after 3 days of treatment,the effective rate of treatment was significantly higher than the control group,there were significant differences between the two groups （P〈0.05）;patients in study group were treated for 3 days after the awakening rate of hepatic encephalopathy was significantly higher than the control group,the two groups compared in statistical difference （P〈0.05）;there is no serious adverse effects in the research group and the control group of patients during treatment.Conclusion The complications of hepatic encephalopathy in clinical comprehensive treatment under the premise of taking the molecular adsorbent recycling system has significant treatment effect,can significantly improve the liver function of patients,enhance the recovery of hepatic encephalopathy,with less adverse reaction,should be popularized in clinical use.