通心络治疗对脑梗死患者颈动脉狭窄程度和超敏C反应蛋白及D-二聚体水平的影响

Effect of Tongxinluo on carotid artery stenosisthe,hs-CRP and D-Dimer in patients with cerebral infarction

目的探讨通心络治疗对脑梗死患者颈动脉狭窄程度、超敏C反应蛋白(hs-CRP)和D-二聚体水平的影响。方法选取2014年6月至2015年6月于该院治疗的168例脑梗死患者,按照随机数字表法分为试验组和对照组,各84例。对照组患者接受常规药物治疗,试验组患者在此基础上加用通心络胶囊,以6个月为1个疗程。治疗前及治疗1个疗程后,采用多普勒超声诊断仪检测颈动脉内中膜厚度、粥样斑块面积和颈动脉狭窄率;抽取患者静脉血检测hs-CRP和D-二聚体水平。结果治疗后,2组患者颈动脉内中膜厚度、粥样斑块面积和颈动脉狭窄率均显著减小,但试验组减少更加显著(P<0.05)。治疗后,2组患者外周血D-二聚体、hs-CRP水平均显著下降,但试验组患者治疗后D-二聚体、hs-CRP水平更低(P<0.05)。结论通心络治疗可有效降低脑梗死患者外周血hs-CRP和D-二聚体水平,延缓颈动脉狭窄,值得推广应用。

Objective To investigate the effect of Tongxinluo on carotid artery stenosis,and the levels of high sensitive C reac-tive protein（hs-CRP） and D-Dimer in patients with cerebral infarction. Methods 168 patients with cerebral infarction treated in this hospital from June 2014 to June 2015 were randomly divided into experimental group and control group, with 84 cases in each group. The patients in both group received routine treatment. In addition to that, patients in the experimental group also used Tongxinluo capsule for 6 months as a course of treatment. After a course of treatment, Doppler ultrasound diagnosis instrument was used to detect carotid arterial intima-media thickness, plaque area and carotid artery stenosis rate. Hs-CRP and D-Dimer levels were also detected. Results After treatment,the carotid arterial intima-media thickness,plaque area and carotid vascular stenosis rate in two group were significantly decreased（P〈0 . 05） ,but the three indicators in experimental group w ere decreased more significantly （P〈0 . 05）. After a course of treatment,the levels of D-Dimer and hs-CRP in peripheral blood of the two groups were significantly decreased（P〈0 . 05） ,but the content of D-Dimer and hs-CRP was much lower in the experimental group（P〈0 . 05）. Conclusion Tongxinluo treatment could effectively reduce the level of hs-CRP and D-Dimer in patients with cerebral infarction,and alleviate thecarotid artery stenosis, which might be worthy of clinical application.