食管癌患者手术前后血管生成相关实验室指标检测意义研究

The significance of correlation laboratory examination in esophageal cancer patients before and after operation

目的探讨食管癌患者手术前后可溶性CD105、转化生长因子β1(TGF-β1)和血管内皮生长因子(VEGF)水平变化,分析可溶性CD105、TGF-β1和VEGF的检测在食管癌患者中的临床意义。方法选取2014年11月至2016年1月入院进行手术的食管癌患者56例(观察组)及同期健康体检者49例(对照组)作为研究对象,分别检测手术前后可溶性CD105、TGF-β1和VEGF的水平,并对数据进行对比分析。结果食管癌患者手术前可溶性CD105、TGF-β1和VEGF的表达水平明显高于对照组、观察组手术后检测结果,两者比较差异有统计学意义(P<0.05);手术后可溶性CD105、TGF-β1和VEGF的表达水平与对照组比较,差异无统计学意义(P>0.05)。结论食管癌患者存在可溶性CD105、TGF-β1和VEGF的表达水平的异常,可溶性CD105、TGF-β1和VEGF的检测对食管癌的病情观察及预后有一定的指导意义。

Objective To investigate the changes of soluble CD105 , transforming growth factor-betal （TGF-β1） and vascular en-dothelial growth factor（VEGF） in esophageal cancer（EC） patients, analyzing its clinical significance. Methods Collecting 56 cases of gastric cancer（observation group） and 49 cases of healthy peopleCcontrol group）from Nov. 2014 to Jan. 2016 as the research ob-jects. The levels of soluble CD105,TGF-β1 and VEGF were detected in EC patients pre-and post-operation and healthy subjects. The data of soluble CD105,TGF-β1 and VEGF were analyzed in the two groups. Results The pre-operation levels of soluble CD105？TGF-β1 and VEGF in EC patients were significantly higher than those in the control group？the difference was statistically significant（P〈0. 05）. The pre-operation levels of soluble CD105,TGF-β1 and VEGF in EC patients were significantly higher than post-operation levels,the difference was statistically significant（P〈0. 05）. The post-operation levels of soluble CD105,TGF-β1and VEGF in EC patients were not statistically different with control group（P〉0. 05）. Conclusion The levels of soluble CD105 ,TGF- β1 and VEGF could be abnormal in patients with EC, which might be the index for monitoring the clinical disease condition and jud-ging the prognosis of the EC.